HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: EP15R (Q60902)
Epidermal growth factor receptor substrate 15-like 1 (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs) (Eps15-related protein) (Eps15R)
Gene: Eps15l1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	27474268
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 913 Mm			1 907
+	Hs
		610520 CBL_HUMAN (1-913): 0: 894: 91.05		EP15R_HUMAN (1-860): 2.72e-148: 461: 92.23
+	Mm
		1112055 CBLB_MOUSE (23-908): 0: 798: 46.14		EP15R_MOUSE (1-907): 2.44e-145: 455: 100.00
+	Mm
		610656 CBL_MOUSE (1-913): 0: 923: 100.00		ITSN1_MOUSE (2-524): 3.68e-35: 147: 14.70
+	Hs
		610415 CBL_HUMAN (1-913): 0: 894: 91.05		ITSN1_HUMAN (2-522): 3.16e-37: 154: 13.52
+	Mm
		610657 CBL_MOUSE (1-913): 0: 923: 100.00		ITSN2_MOUSE (108-783): 1.48e-27: 122: 12.69
+	Hs
		610517 CBL_HUMAN (1-913): 0: 894: 91.05		ITSN2_HUMAN (108-768): 5.75e-23: 108: 12.27
+	Hs
		610530 CBL_HUMAN (1-913): 0: 894: 91.05		MYH2_HUMAN (266-612): 2.87e-14: 79.7: 9.22
+	Hs
		610264 CBL_HUMAN (1-913): 0: 894: 91.05		MYH10_HUMAN (368-627): 1.14e-09: 64.5: 14.71
+	Hs
		1027606 CBLB_HUMAN (23-908): 0: 799: 45.92		ITSN1_HUMAN (2-522): 3.16e-37: 154: 13.52
+	Mm
		1112081 CBLB_MOUSE (23-908): 0: 798: 46.14		ITSN2_MOUSE (108-783): 1.48e-27: 122: 12.69
+	Hs
		1027627 CBLB_HUMAN (23-908): 0: 799: 45.92		ITSN2_HUMAN (108-768): 5.75e-23: 108: 12.27
+	Dm
		112567 O46034_DROME (45-457): 0: 756: 70.29		M9ND00_DROME (1-465): 4.54e-32: 137: 10.71
+	Rn
		1126747 SYNJ1_RAT (533-908): 2.95e-09: 63.4: 11.19		Q5JC29_RAT (1-780): 3.38e-98: 327: 42.34
+	Hs
		990961 ZO1_HUMAN (435-850): 6.77e-22: 104: 14.39		MRCKB_HUMAN (202-842): 1.91e-35: 148: 9.24
+	Hs
		203228 SYNJ1_HUMAN (565-911): 2.87e-09: 63.4: 13.47		ITSN1_HUMAN (2-522): 3.16e-37: 154: 13.52
+	Hs
		257713 ANR17_HUMAN (449-911): 1.89e-09: 64.2: 8.33		ITSN2_HUMAN (108-768): 5.75e-23: 108: 12.27