HitPredict

Interactor 1: LET60 (P22981)
Ras protein let-60 (Abnormal cell lineage protein 34) (Lethal protein 60)
Gene: let-60

Interactor 2: Q8MXF0 (Q8MXF0)
FERM and PDZ domain-containing protein 4
Gene: frm-8

Species: Caenorhabditis elegans

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.80	0.528

Property	Details
Experiments	10615043
Identification Methods	two hybrid pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~Ras, PDZ~Ras, RA~Ras
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 184 Ce			1 853
+	Ce
		612370 LET60_CAEEL (1-184): 6.07e-90: 262: 100.00		Q8ITW4_CAEEL (43-823): 0: 930: 96.30
+	Dm
		442974 RAP1_DROME (1-163): 3.7e-60: 187: 56.10		Q9VFD3_DROME (12-621): 2.74e-171: 538: 29.98
+	Hs
		348876 RASN_HUMAN (1-181): 5.7e-88: 257: 76.80		MAGI1_HUMAN (4-231): 2.03e-40: 163: 17.77
+	Hs
		350257 RASK_HUMAN (1-184): 1.79e-85: 251: 74.60		PKHA7_HUMAN (45-218): 6.1e-41: 165: 17.03
+	Hs
		348866 RASN_HUMAN (1-181): 5.7e-88: 257: 76.80		ITCH_HUMAN (5-197): 4.11e-39: 158: 19.31
+	Hs
		350465 RASK_HUMAN (1-184): 1.79e-85: 251: 74.60		MAGI1_HUMAN (4-231): 2.03e-40: 163: 17.77
+	Hs
		1070251 RAB35_HUMAN (4-181): 6.94e-83: 245: 31.96		PKHA7_HUMAN (45-218): 6.1e-41: 165: 17.03
+	Hs
		350454 RASK_HUMAN (1-184): 1.79e-85: 251: 74.60		ITCH_HUMAN (5-197): 4.11e-39: 158: 19.31
+	Hs
		845887 RAB13_HUMAN (4-180): 4.02e-78: 233: 35.20		WWOX_HUMAN (46-285): 5.95e-45: 169: 18.70
+	Hs
		349631 RASH_HUMAN (1-181): 2.61e-84: 248: 76.80		WWP1_HUMAN (4-271): 6.42e-31: 132: 15.81
+	Dm
		819772 RALA_DROME (4-182): 1.07e-56: 178: 50.28		Q9W2L2_DROME (55-123): 2.43e-20: 99.1: 35.07