HitPredict

Interactor 1: CNOT1 (A5YKK6)
CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1)
Gene: CNOT1

Interactor 2: TOB1 (P50616)
Protein Tob1 (Transducer of erbB-2 1)
Gene: TOB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.704

Property	Details
Experiments	26496610, 28514442, 33961781, 18377426
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0017148 - negative regulation of translation GO:0030014 - CCR4-NOT complex GO:0060213 - positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:1900153 - positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 2376 Hs			1 345
+	Hs
		61360 CNOT1_HUMAN (1-2376): 0: 3468: 100.00		TOB2_HUMAN (1-343): 1.31e-131: 381: 55.38
+	Hs
		61363 CNOT1_HUMAN (1-2376): 0: 3468: 100.00		BTG3_HUMAN (1-165): 4.25e-56: 185: 29.12
+	Hs
		61347 CNOT1_HUMAN (1-2376): 0: 3468: 100.00		BTG2_HUMAN (1-115): 1.32e-53: 175: 41.88