Interactor 1: BDNF (P23560)
Brain-derived neurotrophic factor (BDNF) (Abrineurin) [Cleaved into: BDNF precursor form (ProBDNF)]
Gene: BDNF

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.73 1.00 0.858

The method score is based on:

Property Details
Experiments 21651720, 9312147, 11855816
Identification Methods pull down, surface plasmon resonance
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains I-set~NGF
Common GO terms GO:0010976 - positive regulation of neuron projection development
GO:0030424 - axon
GO:0030425 - dendrite
GO:0031547 - brain-derived neurotrophic factor receptor signaling pathway
GO:0033138 - positive regulation of peptidyl-serine phosphorylation
and 3 others

more...

Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 247
Hs

1 822
+ Mm
+ Rn
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024