HitPredict

Interactor 1: CDK2 (P23573)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 cognate)
Gene: CDK2

Interactor 2: Q961D1 (Q961D1)
Cyclin K, isoform A (Cyclin K, isoform B) (Cyclin K, isoform C) (LD21709p)
Gene: CycK

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	15575970, 16603075, 19079254
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 314 Dm			1 400
+	Hs
		625350 CDK2_HUMAN (5-293): 1.16e-155: 438: 64.73		CCNA1_HUMAN (1-274): 1.02e-79: 254: 15.58
+	Hs
		538471 CDK2_HUMAN (5-293): 1.16e-155: 438: 64.73		CCNB1_HUMAN (5-276): 9.28e-74: 238: 14.34
+	Hs
		590125 CDK2_HUMAN (5-293): 1.16e-155: 438: 64.73		CCNA2_HUMAN (5-273): 1.4e-71: 232: 18.82
+	Hs
		303829 CDK2_HUMAN (5-293): 1.16e-155: 438: 64.73		CCNB2_HUMAN (1-279): 1.2e-71: 231: 12.90
+	Mm
		956329 CDK2_MOUSE (5-293): 5.83e-147: 418: 55.00		CCNA1_MOUSE (5-274): 1.47e-77: 247: 15.44
+	Hs
		538521 CDK3_HUMAN (5-300): 3.85e-149: 422: 62.54		CCNB1_HUMAN (5-276): 9.28e-74: 238: 14.34
+	Hs
		590162 CDK3_HUMAN (5-300): 3.85e-149: 422: 62.54		CCNA2_HUMAN (5-273): 1.4e-71: 232: 18.82
+	Mm
		851183 CDK2_MOUSE (5-293): 5.83e-147: 418: 55.00		CCNA2_MOUSE (5-273): 1.06e-72: 235: 18.08
+	Hs
		624422 CDK3_HUMAN (5-300): 3.85e-149: 422: 62.54		CCNC_HUMAN (3-249): 8.53e-69: 220: 26.59
+	Hs
		960107 CDK3_HUMAN (5-300): 3.85e-149: 422: 62.54		CCNQ_HUMAN (22-239): 1.1e-67: 216: 25.22
+	Mm
		956332 CDK2_MOUSE (5-293): 5.83e-147: 418: 55.00		CCNC_MOUSE (3-249): 1.98e-68: 219: 26.19
+	Dm
		540473 CDK2_DROME (1-314): 2.57e-144: 410: 100.00		CCNA_DROME (5-272): 5.08e-68: 225: 15.93
+	Hs
		236679 CDK1_HUMAN (5-292): 7.45e-140: 398: 57.19		CCNT1_HUMAN (4-307): 1.16e-69: 234: 25.24
+	Hs
		625155 CDK2_HUMAN (5-293): 1.16e-155: 438: 64.73		CCND2_HUMAN (16-275): 4.18e-58: 193: 15.27
+	Hs
		625251 CDK2_HUMAN (5-293): 1.16e-155: 438: 64.73		CCNH_HUMAN (21-265): 1.09e-57: 193: 17.86
+	Hs
		303821 CDK1_HUMAN (5-292): 7.45e-140: 398: 57.19		CCNB2_HUMAN (1-279): 1.2e-71: 231: 12.90
+	Rn
		981205 Q6P751_RAT (5-293): 2.41e-155: 437: 64.04		CCND2_RAT (16-275): 6.89e-57: 189: 15.27
+	Dm
		618425 CDK2_DROME (1-314): 2.57e-144: 410: 100.00		CCNC_DROME (3-243): 1.42e-65: 211: 23.98
+	Hs
		851197 CDK3_HUMAN (5-300): 3.85e-149: 422: 62.54		CCNH_HUMAN (21-265): 1.09e-57: 193: 17.86
+	Mm
		673122 CDK2_MOUSE (5-293): 5.83e-147: 418: 55.00		CCND2_MOUSE (16-263): 4.03e-57: 190: 16.67