HitPredict

Interactor 1: IRF8 (P23611)
Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (ICSBP)
Gene: IRF8

Interactor 2: ISG15 (Q64339)
Ubiquitin-like protein ISG15 (Interferon-induced 15 kDa protein) (Interferon-induced 17 kDa protein) (IP17) (Ubiquitin cross-reactive protein)
Gene: ISG15

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	10981959
Identification Methods	electrophoretic mobility supershift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0009617 - response to bacterium GO:0032729 - positive regulation of type II interferon production GO:0042742 - defense response to bacterium
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 424 Mm			1 161
+	Hs
		397918 IRF8_HUMAN (1-424): 0: 574: 89.67		ISG15_HUMAN (3-82): 3.14e-09: 54.5: 26.25
+	Hs
		475026 IRF3_HUMAN (9-388): 6.95e-146: 423: 28.72		UBB_HUMAN (2-155): 4.43e-64: 197: 33.12
+	Mm
		476725 IRF5_MOUSE (9-422): 1.81e-165: 476: 33.04		UBC_MOUSE (2-108): 5.91e-32: 121: 29.91
+	Mm
		936898 IRF3_MOUSE (9-396): 7.44e-136: 397: 24.69		ISG15_MOUSE (1-161): 4.54e-49: 157: 100.00
+	Hs
		397980 IRF4_HUMAN (6-384): 4.64e-155: 447: 42.27		ISG15_HUMAN (3-82): 3.14e-09: 54.5: 26.25
+	Hs
		397967 IRF3_HUMAN (9-388): 6.95e-146: 423: 28.72		ISG15_HUMAN (3-82): 3.14e-09: 54.5: 26.25
+	Hs
		397915 IRF9_HUMAN (5-385): 1.13e-130: 383: 34.01		ISG15_HUMAN (3-82): 3.14e-09: 54.5: 26.25
+	Hs
		398058 IRF7_HUMAN (12-383): 4.85e-111: 337: 21.46		ISG15_HUMAN (3-82): 3.14e-09: 54.5: 26.25
+	Hs
		397741 IRF1_HUMAN (9-266): 9.31e-86: 266: 27.27		ISG15_HUMAN (3-82): 3.14e-09: 54.5: 26.25
+	Hs
		397754 IRF2_HUMAN (9-167): 5.93e-59: 197: 37.50		ISG15_HUMAN (3-82): 3.14e-09: 54.5: 26.25