HitPredict

Interactor 1: RPB3 (P19387)
DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31)
Gene: POLR2C

Interactor 2: RPB1 (P24928)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: POLR2A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.962

The method score is based on:

Property Details
Experiments 9201987, 35271311, 37682711, 19240132, 24981860, 34079125, 18562274
Identification Methods pull down, affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains RNA_pol_L~RNA_pol_Rpb1_2, RNA_pol_L~RNA_pol_Rpb1_3, RNA_pol_L~RNA_pol_Rpb1_4, RNA_pol_L~RNA_pol_Rpb1_5
Common GO terms GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005665 - RNA polymerase II, core complex
and 1 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 275
Hs

1 1970
+ Bt
+ Hs
+ Sp
+ Sc
+ Hs
+ Hs
+ Sc
+ Sc
+ Sc
+ Sc
+ Hv
+ At
+ At
+ Hs
+ Hs
+ At
+ At
+ Dm
+ Hv

Service provided by Combinatics, Japan

Last updated: 11Aug2025