HitPredict

Interactor 1: CCND1 (P24385)
G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)
Gene: CCND1

Interactor 2: CKS1 (P61024)
Cyclin-dependent kinases regulatory subunit 1 (CKS-1)
Gene: CKS1B

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	8479754
Identification Methods	biophysical
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005654 - nucleoplasm GO:0019901 - protein kinase binding GO:0051301 - cell division GO:0061575 - cyclin-dependent protein serine/threonine kinase activator activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 295 Hs			1 79
+	At
		188148 CCA23_ARATH (9-284): 4.76e-96: 292: 23.11		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	At
		1324477 CCA31_ARATH (3-281): 1.02e-96: 290: 25.00		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	Hs
		895411 CCNA1_HUMAN (7-281): 7.64e-89: 274: 23.91		CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00
+	Hs
		538505 CCNB1_HUMAN (5-282): 3.94e-89: 273: 20.64		CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00
+	Hs
		706795 CCNA1_HUMAN (7-281): 7.64e-89: 274: 23.91		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	At
		188151 CCA34_ARATH (1-281): 9.35e-90: 273: 21.45		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	Hs
		538483 CCNB1_HUMAN (5-282): 3.94e-89: 273: 20.64		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	At
		1108315 CCA34_ARATH (1-281): 9.35e-90: 273: 21.45		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	At
		48925 CCA33_ARATH (8-284): 1.14e-89: 271: 20.36		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	At
		48953 CCA33_ARATH (8-284): 1.14e-89: 271: 20.36		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	Hs
		303840 CCNB2_HUMAN (7-287): 1.34e-85: 263: 18.09		CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00
+	Hs
		303832 CCNB2_HUMAN (7-287): 1.34e-85: 263: 18.09		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	At
		188178 CCB24_ARATH (2-281): 7.3e-84: 260: 20.14		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	At
		1352139 CCB24_ARATH (2-281): 7.3e-84: 260: 20.14		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	Hs
		590156 CCNA2_HUMAN (3-286): 6.9e-81: 252: 24.48		CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00
+	At
		188167 CCB23_ARATH (2-276): 1.46e-81: 254: 19.93		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	Hs
		590135 CCNA2_HUMAN (3-286): 6.9e-81: 252: 24.48		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	At
		188149 CCB12_ARATH (7-285): 1.18e-79: 249: 22.42		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	At
		1106919 CCB12_ARATH (7-285): 1.18e-79: 249: 22.42		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	Sc
		594111 CG23_YEAST (21-247): 1.9e-78: 246: 23.79		CKS1_YEAST (3-73): 3.34e-32: 110: 50.00