HitPredict

Interactor 1: CXCL2 (P19875)
C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)]
Gene: CXCL2

Interactor 2: CXCL3 (P19876)
C-X-C motif chemokine 3 (GRO-gamma(1-73)) (Growth-regulated protein gamma) (GRO-gamma) (Macrophage inflammatory protein 2-beta) (MIP2-beta) [Cleaved into: GRO-gamma(5-73)]
Gene: CXCL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006954 - inflammatory response GO:0006955 - immune response GO:0008009 - chemokine activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 107 Hs			1 107
+	Hs
		480484 CXCL2_HUMAN (1-107): 5.53e-34: 114: 100.00		GROA_HUMAN (1-107): 2.6e-31: 108: 86.92
+	Hs
		480485 CXCL3_HUMAN (1-107): 9.67e-32: 109: 87.85		GROA_HUMAN (1-107): 2.6e-31: 108: 86.92
+	Hs
		480482 GROA_HUMAN (1-107): 2.32e-31: 108: 89.72		GROA_HUMAN (1-107): 2.6e-31: 108: 86.92
+	Hs
		626424 CXCL2_HUMAN (1-107): 5.53e-34: 114: 100.00		CXCL5_HUMAN (30-105): 2.89e-26: 95.5: 48.68
+	Hs
		626430 CXCL2_HUMAN (1-107): 5.53e-34: 114: 100.00		CXCL6_HUMAN (30-105): 6.19e-25: 92.1: 42.11
+	Hs
		518762 CXCL2_HUMAN (1-107): 5.53e-34: 114: 100.00		IL8_HUMAN (30-107): 9.69e-25: 91.3: 37.98
+	Hs
		626441 CXCL3_HUMAN (1-107): 9.67e-32: 109: 87.85		CXCL5_HUMAN (30-105): 2.89e-26: 95.5: 48.68
+	Hs
		480489 GROA_HUMAN (1-107): 2.32e-31: 108: 89.72		CXCL5_HUMAN (30-105): 2.89e-26: 95.5: 48.68
+	Hs
		626443 CXCL3_HUMAN (1-107): 9.67e-32: 109: 87.85		CXCL6_HUMAN (30-105): 6.19e-25: 92.1: 42.11
+	Hs
		480494 GROA_HUMAN (1-107): 2.32e-31: 108: 89.72		CXCL6_HUMAN (30-105): 6.19e-25: 92.1: 42.11
+	Hs
		390311 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		CXCL7_HUMAN (25-106): 4.36e-28: 100: 45.12
+	Hs
		390359 CXCL2_HUMAN (1-107): 5.53e-34: 114: 100.00		PLF4_HUMAN (40-103): 3.08e-21: 82.4: 42.19
+	Hs
		626432 CXCL2_HUMAN (1-107): 5.53e-34: 114: 100.00		CXCL9_HUMAN (33-99): 6.41e-20: 79.7: 45.59
+	Hs
		158933 CXCL2_HUMAN (1-107): 5.53e-34: 114: 100.00		CXL11_HUMAN (14-103): 6.65e-20: 79: 28.26
+	Hs
		390328 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		CXCL6_HUMAN (30-105): 6.19e-25: 92.1: 42.11
+	Hs
		390312 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		CXL10_HUMAN (17-102): 3.65e-21: 82: 22.73
+	Hs
		390329 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		CXCL9_HUMAN (33-99): 6.41e-20: 79.7: 45.59
+	Hs
		158925 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		CXL11_HUMAN (14-103): 6.65e-20: 79: 28.26