Protein: GROA
Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)]

Gene: GROA, CXCL1
Organism: Homo sapiens
Interactions: 32
UniProt ID: P09341

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006935 - chemotaxis
GO:0006954 - inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

480487

CXCR2
C-X-C chemokine receptor type 2

9

20

Small-scale

0.957

High

480489

CXCL5
C-X-C motif chemokine 5

1

17

High-throughput

0.692

High

480491

CCL11
Eotaxin

1

20

High-throughput

0.692

High

480494

CXCL6
C-X-C motif chemokine 6

1

17

High-throughput

0.692

High

480482

GROA
Growth-regulated alpha protein

1

17

Small-scale

0.691

High

480484

CXCL2
C-X-C motif chemokine 2

1

18

High-throughput

0.691

High

480485

CXCL3
C-X-C motif chemokine 3

1

18

High-throughput

0.691

High

480499

ACKR1
Atypical chemokine receptor 1

4

20

Small-scale

0.686

High

378943

PIGR
Polymeric immunoglobulin receptor

1

2

Small-scale

0.618

High

480486

CXCR1
C-X-C chemokine receptor type 1

1

20

Small-scale

0.618

High

480497

TRAF2
TNF receptor-associated factor 2

2

1

High-throughput

0.601

High

480496

TF65
Transcription factor p65

2

15

Small-scale

0.584

High

480498

BIRC2
Baculoviral IAP repeat-containing protein 2

2

4

High-throughput

0.549

High

480505

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

2

5

High-throughput

0.549

High

374351

RASH
GTPase HRas

1

1

High-throughput

0.541

High

395356

ESR1
Estrogen receptor

1

2

High-throughput

0.541

High

480507

TBK1
Serine/threonine-protein kinase TBK1

1

2

High-throughput

0.536

High

480492

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.518

High

480495

XIAP
E3 ubiquitin-protein ligase XIAP

1

4

High-throughput

0.489

High

480500

Q6FHY5
MEOX2 protein

1

3

High-throughput

0.470

High

480483

PARP1
Poly [ADP-ribose] polymerase 1

1

0

Small-scale

0.458

High

480488

MMP12
Macrophage metalloelastase

1

20

Small-scale

0.445

High

480490

MEOX2
Homeobox protein MOX-2

1

3

High-throughput

0.439

High

480503

TOLIP
Toll-interacting protein

1

0

High-throughput

0.426

High

480502

SEH1
Nucleoporin SEH1

2

0

High-throughput

0.313

High

480504

HIPK2
Homeodomain-interacting protein kinase 2

1

0

Small-scale

0.292

High

219910

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.282

High

480506

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.279

Low

480501

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

0

High-throughput

0.269

Low

480493

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.249

Low

133722

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025