Protein: SPRE
Sepiapterin reductase (SPR) (EC 1.1.1.153)

Gene: SPRE, SPR
Organism: Homo sapiens
Interactions: 35
UniProt ID: P35270

Gene Ontology (top 5):
GO:0004033 - aldo-keto reductase (NADPH) activity
GO:0004757 - sepiapterin reductase (NADP+) activity
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006729 - tetrahydrobiopterin biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

361833

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

2

High-throughput

0.536

High

722666

BAP31
B-cell receptor-associated protein 31

1

2

High-throughput

0.515

High

135811

MA2B1
Lysosomal alpha-mannosidase

1

0

High-throughput

0.513

High

646677

1433T
14-3-3 protein theta

1

1

High-throughput

0.501

High

410611

CD5
T-cell surface glycoprotein CD5

1

2

High-throughput

0.489

High

722667

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

128974

PLK4
Serine/threonine-protein kinase PLK4

1

1

High-throughput

0.479

High

160413

AURKA
Aurora kinase A

1

1

High-throughput

0.479

High

165938

PER2
Period circadian protein homolog 2

1

1

Small-scale

0.479

High

337373

ABL1
Tyrosine-protein kinase ABL1

1

6

High-throughput

0.479

High

346085

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

411320

INSR
Insulin receptor

1

1

High-throughput

0.479

High

412055

FYN
Tyrosine-protein kinase Fyn

1

6

High-throughput

0.479

High

433270

YES
Tyrosine-protein kinase Yes

1

6

High-throughput

0.479

High

433619

LYN
Tyrosine-protein kinase Lyn

1

6

High-throughput

0.479

High

503552

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

522821

SRC
Proto-oncogene tyrosine-protein kinase Src

1

6

High-throughput

0.479

High

552076

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

650506

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

719815

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

722663

TEC
Tyrosine-protein kinase Tec

1

6

High-throughput

0.479

High

722664

ABL2
Tyrosine-protein kinase ABL2

1

6

High-throughput

0.479

High

722668

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.479

High

722673

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

722677

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

722669

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

722670

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

722671

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

722674

RNF31
E3 ubiquitin-protein ligase RNF31

1

7

High-throughput

0.445

High

435560

IGF1R
Insulin-like growth factor 1 receptor

1

1

High-throughput

0.437

High

722672

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

722675

VPS35
Vacuolar protein sorting-associated protein 35

1

0

Small-scale

0.426

High

722665

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

722676

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

722678

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024