Protein: IL8
Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (T-cell chemotactic factor) [Cleaved into: MDNCF-a (GCP/IL-8 protein IV) (IL8/NAP1 form I); Interleukin-8 ((Ala-IL-8)77) (GCP/IL-8 protein II) (IL-8(1-77)) (IL8/NAP1 form II) (MDNCF-b); IL-8(5-77); IL-8(6-77) ((Ser-IL-8)72) (GCP/IL-8 protein I) (IL8/NAP1 form III) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (MDNCF-c) (Neutrophil-activating factor) (NAF); IL-8(7-77) (GCP/IL-8 protein V) (IL8/NAP1 form IV); IL-8(8-77) (GCP/IL-8 protein VI) (IL8/NAP1 form V); IL-8(9-77) (GCP/IL-8 protein III) (IL8/NAP1 form VI)]

Gene: IL8, CXCL8
Organism: Homo sapiens
Interactions: 57
UniProt ID: P10145

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0002237 - response to molecule of bacterial origin
GO:0005153 - interleukin-8 receptor binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

518766

CXCR2
C-X-C chemokine receptor type 2

18

20

Small-scale

0.985

High

518765

CXCR1
C-X-C chemokine receptor type 1

12

20

Small-scale

0.978

High

518752

IL8
Interleukin-8

5

17

Small-scale

0.920

High

390355

PLF4
Platelet factor 4

2

18

Small-scale

0.811

High

518780

TF65
Transcription factor p65

18

15

Small-scale

0.762

High

518787

ACKR1
Atypical chemokine receptor 1

6

20

Small-scale

0.727

High

518761

NFKB1
Nuclear factor NF-kappa-B p105 subunit

6

15

Small-scale

0.724

High

518754

CCL2
C-C motif chemokine 2

1

20

High-throughput

0.692

High

518775

CCL8
C-C motif chemokine 8

1

20

High-throughput

0.692

High

429187

JUN
Transcription factor Jun

3

6

Small-scale

0.650

High

518758

CEBPB
CCAAT/enhancer-binding protein beta

3

1

Small-scale

0.650

High

518755

CCL5
C-C motif chemokine 5

1

20

Small-scale

0.647

High

378945

PIGR
Polymeric immunoglobulin receptor

1

2

Small-scale

0.618

High

518762

CXCL2
C-X-C motif chemokine 2

1

18

Small-scale

0.618

High

518770

CXCL5
C-X-C motif chemokine 5

1

18

Small-scale

0.618

High

518782

EP300
Histone acetyltransferase p300

3

1

Small-scale

0.606

High

370523

FOS
Protein c-Fos

2

2

Small-scale

0.584

High

518753

IRF1
Interferon regulatory factor 1

2

10

Small-scale

0.584

High

518759

EGR1
Early growth response protein 1

2

1

Small-scale

0.584

High

518764

RS3
Small ribosomal subunit protein uS3

2

0

Small-scale

0.559

High

399261

MMP1
Interstitial collagenase

2

20

Small-scale

0.552

High

518756

MMP9
Matrix metalloproteinase-9

2

20

Small-scale

0.552

High

518776

TSG6
Tumor necrosis factor-inducible gene 6 protein

1

4

Small-scale

0.536

High

518784

IRF3
Interferon regulatory factor 3

2

10

Small-scale

0.533

High

369597

A2MG
Alpha-2-macroglobulin

1

1

Small-scale

0.515

High

518760

SDC1
Syndecan-1

1

1

Small-scale

0.512

High

518773

MMP14
Matrix metalloproteinase-14

1

20

Small-scale

0.501

High

410548

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

0

Small-scale

0.480

High

167800

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.479

High

177774

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

2

Small-scale

0.479

High

403768

GCR
Glucocorticoid receptor

1

2

Small-scale

0.479

High

418575

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

1

Small-scale

0.479

High

518779

RELB
Transcription factor RelB

1

15

Small-scale

0.479

High

518781

REL
Proto-oncogene c-Rel

1

15

Small-scale

0.479

High

518757

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

Small-scale

0.458

High

518767

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

518778

TIAR
Nucleolysin TIAR

1

0

Small-scale

0.458

High

518785

TRIP6
Thyroid receptor-interacting protein 6

1

0

Small-scale

0.458

High

518763

MMP8
Neutrophil collagenase

1

20

Small-scale

0.445

High

518769

MMP12
Macrophage metalloelastase

1

20

Small-scale

0.445

High

518771

MMP13
Collagenase 3

1

20

Small-scale

0.445

High

518772

BAG6
Large proline-rich protein BAG6

1

2

High-throughput

0.439

High

518774

NAL12
NACHT, LRR and PYD domains-containing protein 12

1

0

Small-scale

0.438

High

518768

AHR
Aryl hydrocarbon receptor

1

1

Small-scale

0.437

High

518777

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

15

Small-scale

0.437

High

518783

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

1

Small-scale

0.437

High

469403

ELNE
Neutrophil elastase

1

0

Small-scale

0.426

High

518786

ELAV1
ELAV-like protein 1

3

0

Small-scale

0.334

High

518789

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

0

High-throughput

0.282

High

518792

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

0

High-throughput

0.282

High

226683

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

0

High-throughput

0.251

Low

188151

HDAC3
Histone deacetylase 3

1

0

Small-scale

0.249

Low

518788

H31T
Histone H3.1t

1

0

Small-scale

0.249

Low

518790

FUBP2
Far upstream element-binding protein 2

1

0

Small-scale

0.249

Low

518791

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

0

Small-scale

0.249

Low

518793

NCOR2
Nuclear receptor corepressor 2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025