Protein: CXCL6
C-X-C motif chemokine 6 (Chemokine alpha 3) (CKA-3) (Granulocyte chemotactic protein 2) (GCP-2) (Small-inducible cytokine B6) [Cleaved into: Small-inducible cytokine B6, N-processed variant 1; Small-inducible cytokine B6, N-processed variant 2; Small-inducible cytokine B6, N-processed variant 3]

Gene: CXCL6
Organism: Homo sapiens
Interactions: 39
UniProt ID: P80162

Gene Ontology (top 5):
GO:0001776 - leukocyte homeostasis
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006935 - chemotaxis
GO:0006954 - inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

390366

PLF4
Platelet factor 4

1

18

High-throughput

0.716

High

562888

CCL5
C-C motif chemokine 5

1

20

High-throughput

0.716

High

870199

SDF1
Stromal cell-derived factor 1

1

7

High-throughput

0.716

High

390328

CXCL7
Platelet basic protein

1

17

High-throughput

0.692

High

390393

CXL10
C-X-C motif chemokine 10

1

17

High-throughput

0.692

High

480494

GROA
Growth-regulated alpha protein

1

17

High-throughput

0.692

High

626430

CXCL2
C-X-C motif chemokine 2

1

17

High-throughput

0.692

High

626443

CXCL3
C-X-C motif chemokine 3

1

17

High-throughput

0.692

High

906849

CCL11
Eotaxin

1

20

High-throughput

0.692

High

1009598

CCL8
C-C motif chemokine 8

1

20

High-throughput

0.692

High

1009605

CCL7
C-C motif chemokine 7

1

20

High-throughput

0.692

High

668190

CXCR1
C-X-C chemokine receptor type 1

1

20

Small-scale

0.618

High

668211

CXCR2
C-X-C chemokine receptor type 2

1

20

Small-scale

0.618

High

575783

MMP9
Matrix metalloproteinase-9

2

20

Small-scale

0.585

High

1009624

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

1

High-throughput

0.536

High

171226

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

0

High-throughput

0.513

High

1009632

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.513

High

1009634

KC1G3
Casein kinase I isoform gamma-3

1

0

High-throughput

0.513

High

618454

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

1

1

High-throughput

0.489

High

772739

MYH9
Myosin-9

1

1

High-throughput

0.489

High

1009618

MPRIP
Myosin phosphatase Rho-interacting protein

1

2

High-throughput

0.489

High

1009619

MYH14
Myosin-14

1

1

High-throughput

0.489

High

1009623

SETD2
Histone-lysine N-methyltransferase SETD2

1

3

High-throughput

0.489

High

1009625

K1549
UPF0606 protein KIAA1549

1

1

High-throughput

0.489

High

1009626

MYO5C
Unconventional myosin-Vc

1

2

High-throughput

0.489

High

1009628

TMOD2
Tropomodulin-2

1

1

High-throughput

0.489

High

1009629

RAI14
Ankycorbin

1

2

High-throughput

0.489

High

1009630

MYO5B
Unconventional myosin-Vb

1

2

High-throughput

0.489

High

1009633

MYO5A
Unconventional myosin-Va

1

2

High-throughput

0.489

High

399275

MMP1
Interstitial collagenase

1

20

Small-scale

0.445

High

814897

MMP12
Macrophage metalloelastase

1

20

Small-scale

0.445

High

336399

SVIL
Supervillin

1

0

High-throughput

0.279

Low

597355

GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

1

0

High-throughput

0.279

Low

1009617

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.279

Low

1009620

OCC1
Overexpressed in colon carcinoma 1 protein

1

0

High-throughput

0.279

Low

1009621

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.279

Low

1009622

LRCH3
DISP complex protein LRCH3

1

0

High-throughput

0.279

Low

1009627

ARGL1
Arginine and glutamate-rich protein 1

1

0

High-throughput

0.279

Low

1009631

ADIP
Afadin- and alpha-actinin-binding protein

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025