HitPredict

Interactor 1: CXCL3 (P19876)
C-X-C motif chemokine 3 (GRO-gamma(1-73)) (Growth-regulated protein gamma) (GRO-gamma) (Macrophage inflammatory protein 2-beta) (MIP2-beta) [Cleaved into: GRO-gamma(5-73)]
Gene: CXCL3

Interactor 2: CXCL5 (P42830)
C-X-C motif chemokine 5 (ENA-78(1-78)) (Epithelial-derived neutrophil-activating protein 78) (Neutrophil-activating peptide ENA-78) (Small-inducible cytokine B5) [Cleaved into: ENA-78(8-78); ENA-78(9-78)]
Gene: CXCL5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	28381538
Identification Methods	pull down, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006954 - inflammatory response GO:0008009 - chemokine activity GO:0030593 - neutrophil chemotaxis
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 107 Hs			1 114
+	Hs
		626424 CXCL2_HUMAN (1-107): 2.02e-33: 113: 87.85		CXCL5_HUMAN (1-114): 1.6e-39: 129: 100.00
+	Hs
		480489 GROA_HUMAN (1-107): 2.6e-31: 108: 86.92		CXCL5_HUMAN (1-114): 1.6e-39: 129: 100.00
+	Hs
		626430 CXCL2_HUMAN (1-107): 2.02e-33: 113: 87.85		CXCL6_HUMAN (1-114): 2.7e-34: 116: 79.83
+	Hs
		626443 CXCL3_HUMAN (1-107): 1.08e-31: 109: 100.00		CXCL6_HUMAN (1-114): 2.7e-34: 116: 79.83
+	Hs
		480494 GROA_HUMAN (1-107): 2.6e-31: 108: 86.92		CXCL6_HUMAN (1-114): 2.7e-34: 116: 79.83
+	Hs
		390328 CXCL7_HUMAN (25-106): 4.36e-28: 100: 45.12		CXCL6_HUMAN (1-114): 2.7e-34: 116: 79.83
+	Hs
		626419 CXCL2_HUMAN (1-107): 2.02e-33: 113: 87.85		CXCL3_HUMAN (43-112): 9.97e-27: 96.7: 51.43
+	Hs
		480484 CXCL2_HUMAN (1-107): 2.02e-33: 113: 87.85		GROA_HUMAN (43-112): 2.34e-26: 95.9: 50.00
+	Hs
		390359 CXCL2_HUMAN (1-107): 2.02e-33: 113: 87.85		PLF4_HUMAN (34-109): 4.29e-26: 95.1: 42.11
+	Hs
		480485 CXCL3_HUMAN (1-107): 1.08e-31: 109: 100.00		GROA_HUMAN (43-112): 2.34e-26: 95.9: 50.00
+	Hs
		480482 GROA_HUMAN (1-107): 2.6e-31: 108: 86.92		GROA_HUMAN (43-112): 2.34e-26: 95.9: 50.00
+	Hs
		518762 CXCL2_HUMAN (1-107): 2.02e-33: 113: 87.85		IL8_HUMAN (44-113): 8.71e-24: 89: 36.62
+	Hs
		390311 CXCL7_HUMAN (25-106): 4.36e-28: 100: 45.12		CXCL7_HUMAN (43-114): 4.07e-27: 98.6: 50.00
+	Hs
		626432 CXCL2_HUMAN (1-107): 2.02e-33: 113: 87.85		CXCL9_HUMAN (39-105): 1.52e-20: 81.6: 39.71
+	Hs
		158933 CXCL2_HUMAN (1-107): 2.02e-33: 113: 87.85		CXL11_HUMAN (35-109): 1.33e-20: 80.9: 23.38
+	Hs
		158925 CXCL7_HUMAN (25-106): 4.36e-28: 100: 45.12		CXL11_HUMAN (35-109): 1.33e-20: 80.9: 23.38
+	Hs
		390312 CXCL7_HUMAN (25-106): 4.36e-28: 100: 45.12		CXL10_HUMAN (36-114): 3.25e-20: 80.1: 25.93