HitPredict

Interactor 1: WTIP (A6NIX2)
Wilms tumor protein 1-interacting protein (WT1-interacting protein)
Gene: WTIP

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	20303269, 32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0046872 - metal ion binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 430 Hs			1 1088
+	Hs
		1344960 LIMD1_HUMAN (16-422): 2.4e-72: 241: 46.28		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		1294456 AJUBA_HUMAN (62-422): 2.24e-63: 214: 43.92		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		1080797 ZYX_HUMAN (23-414): 1.23e-56: 197: 28.40		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		63200 WTIP_HUMAN (1-430): 1.53e-85: 269: 100.00		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325930 LIMD1_HUMAN (16-422): 2.4e-72: 241: 46.28		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325743 TRIP6_HUMAN (77-420): 5.82e-66: 220: 35.16		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325852 AJUBA_HUMAN (62-422): 2.24e-63: 214: 43.92		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325748 ZYX_HUMAN (23-414): 1.23e-56: 197: 28.40		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Dm
		1360821 AJUBA_DROME (91-427): 3.81e-66: 226: 47.18		WARTS_DROME (167-1039): 7.21e-137: 443: 39.71
+	Dm
		1210946 Q8I0G8_DROME (196-426): 3.24e-64: 216: 45.26		WARTS_DROME (167-1039): 7.21e-137: 443: 39.71
+	Dm
		1341739 Q9N675_DROME (196-426): 2.04e-63: 215: 45.26		WARTS_DROME (167-1039): 7.21e-137: 443: 39.71
+	Rn
		448415 PDLI5_RAT (7-412): 8.34e-64: 217: 18.74		KPCE_RAT (554-1010): 2.62e-128: 410: 29.49
+	Mm
		554947 LDB3_MOUSE (5-343): 3.89e-33: 133: 14.96		KPCE_MOUSE (554-1010): 2.84e-130: 415: 29.92
+	Mm
		554924 PDLI5_MOUSE (2-277): 3.56e-14: 76.5: 11.19		KPCE_MOUSE (554-1010): 2.84e-130: 415: 29.92
+	Hs
		969104 PDLI5_HUMAN (2-277): 5.69e-14: 75.8: 12.41		KPCE_HUMAN (554-1010): 1.06e-129: 413: 29.92
+	Ce
		107594 G5EFG1_CAEEL (22-410): 9.46e-64: 219: 19.81		ROCK_CAEEL (653-1006): 1.47e-65: 243: 37.19
+	Hs
		823386 PAXI_HUMAN (33-415): 1.11e-48: 176: 16.71		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77