HitPredict

Interactor 1: MSH2 (P25847)
DNA mismatch repair protein MSH2 (MutS protein homolog 2)
Gene: MSH2

Interactor 2: MLH1 (P38920)
DNA mismatch repair protein MLH1 (MutL protein homolog 1) (Post meiotic segregation protein 2)
Gene: MLH1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.963

The method score is based on:

Property Details
Experiments 8066446, 12529393, 9545323, 36215471, 24550389, 15811858, 24811092
Identification Methods comigration in non denaturing gel electrophoresis, pull down, biochemical
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains HATPase_c_3~MutS_II, HATPase_c_3~MutS_III, HATPase_c_3~MutS_V
Common GO terms GO:0000710 - meiotic mismatch repair
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0006298 - mismatch repair
GO:0016887 - ATP hydrolysis activity
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 964
Sc

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024