HitPredict

Interactor 1: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Interactor 2: FBXW8 (Q8N3Y1)
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)
Gene: FBXW8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20558726
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 598
+	Hs
		639784 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		FBXW7_HUMAN (285-590): 1.43e-81: 272: 13.88
+	Hs
		961417 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		FBXW7_HUMAN (285-590): 1.43e-81: 272: 13.88
+	Mm
		1112935 IKBA_MOUSE (1-317): 2.2e-78: 243: 91.17		FBW1A_MOUSE (287-594): 6.07e-62: 217: 13.64
+	Mm
		222603 IKBE_MOUSE (70-315): 8.59e-76: 238: 36.00		FBW1A_MOUSE (287-594): 6.07e-62: 217: 13.64
+	Hs
		639829 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		639819 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Mm
		1131318 IKBA_MOUSE (1-317): 2.2e-78: 243: 91.17		FBW1B_MOUSE (420-593): 1.08e-32: 134: 18.79
+	Hs
		121606 IKBE_HUMAN (3-315): 1.28e-74: 239: 32.10		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		121601 IKBE_HUMAN (3-315): 1.28e-74: 239: 32.10		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		961451 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		961443 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		862124 DAPK1_HUMAN (27-317): 1.12e-62: 216: 17.11		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		72802 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		B4DH70_HUMAN (420-593): 7.75e-33: 134: 18.23
+	Hs
		883676 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		1330889 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		883666 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		1330876 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		1302644 Q96T11_HUMAN (136-316): 4.96e-33: 130: 23.76		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		883544 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		TRAF7_HUMAN (257-500): 1.2e-22: 104: 17.38
+	Hs
		1163035 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		TRAF7_HUMAN (257-500): 1.2e-22: 104: 17.38