HitPredict

Interactor 1: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Interactor 2: FBW1B (Q9UKB1)
F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)
Gene: FBXW11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.761

Property	Details
Experiments	26186194, 28514442, 33961781, 10230406, 10066435, 12165731, 17698585, 27565346, 10644755, 18723677, 36608670, 24912152, 14743216
Identification Methods	affinity chromatography technology, pull down, enzymatic study, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 542
+	Mm
		1131318 IKBA_MOUSE (1-317): 2.2e-78: 243: 91.17		FBW1B_MOUSE (1-542): 1.13e-173: 503: 99.63
+	Hs
		121601 IKBE_HUMAN (3-315): 1.28e-74: 239: 32.10		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		961443 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		862124 DAPK1_HUMAN (27-317): 1.12e-62: 216: 17.11		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		639829 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Mm
		1112935 IKBA_MOUSE (1-317): 2.2e-78: 243: 91.17		FBW1A_MOUSE (36-542): 4.82e-154: 455: 85.27
+	Hs
		121606 IKBE_HUMAN (3-315): 1.28e-74: 239: 32.10		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Mm
		222603 IKBE_MOUSE (70-315): 8.59e-76: 238: 36.00		FBW1A_MOUSE (36-542): 4.82e-154: 455: 85.27
+	Hs
		961451 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		883666 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		1330876 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		1302644 Q96T11_HUMAN (136-316): 4.96e-33: 130: 23.76		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		883676 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		1330889 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		72802 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		B4DH70_HUMAN (40-542): 5.29e-155: 454: 98.41
+	Hs
		639784 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		FBXW7_HUMAN (18-424): 1.12e-72: 246: 20.29
+	Hs
		961417 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		FBXW7_HUMAN (18-424): 1.12e-72: 246: 20.29
+	Hs
		121550 IKBE_HUMAN (3-315): 1.28e-74: 239: 32.10		PRP4_HUMAN (320-536): 4.83e-42: 159: 22.13
+	Hs
		883544 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		TRAF7_HUMAN (353-522): 1.18e-28: 122: 27.17
+	Hs
		1163035 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		TRAF7_HUMAN (353-522): 1.18e-28: 122: 27.17