HitPredict

Interactor 1: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 26496610, 22081069, 18519641, 19959994, 26865630, 32246052, 21896478, 16547522, 18957422, 15218148, 21862596, 11830587, 11064457, 15670770, 15749833, 17363973, 18429822, 21811235, 21217772, 23746843 and 8 others

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Identification Methods affinity chromatography technology, enzymatic study, tandem affinity purification, in-gel kinase assay, protein kinase assay, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank_2~CC2-LZ
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006915 - apoptotic process
and 3 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 317
Hs

1 419
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Last updated: 15 Jul 2024