HitPredict

Interactor 1: C5AR1 (P21730)
C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88)
Gene: C5AR1

Interactor 2: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12464600
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005886 - plasma membrane GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 350 Hs			1 409
+	Hs
		458293 ADRB2_HUMAN (42-339): 8.83e-69: 222: 17.72		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Rn
		708824 Q8VBU7_RAT (40-349): 2.37e-70: 227: 19.42		ARRB2_RAT (1-409): 0: 682: 95.85
+	Hs
		882414 CCR5_HUMAN (17-345): 9.2e-79: 246: 21.35		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		732448 APJ_HUMAN (18-343): 5.09e-67: 217: 24.71		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		732458 OPRD_HUMAN (5-344): 4.76e-67: 217: 23.65		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		720645 AGTR1_HUMAN (26-348): 5.59e-66: 213: 23.65		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		640375 C5AR1_HUMAN (1-350): 1.36e-75: 238: 100.00		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Rn
		669095 AGTRA_RAT (26-348): 2.27e-66: 215: 23.35		ARRB2_RAT (1-409): 0: 682: 95.85
+	Hs
		832360 OPRD_HUMAN (5-344): 4.76e-67: 217: 23.65		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		720652 AGTR1_HUMAN (26-348): 5.59e-66: 213: 23.65		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Rn
		669094 AGTRA_RAT (26-348): 2.27e-66: 215: 23.35		ARRB1_RAT (1-399): 0: 654: 76.90
+	Mm
		715218 AGTRA_MOUSE (26-345): 3.88e-66: 214: 23.57		ARRB1_MOUSE (1-399): 0: 652: 76.90
+	Hs
		732484 AGTR2_HUMAN (42-339): 5.92e-25: 105: 29.62		ARRB2_HUMAN (1-409): 0: 688: 100.00