HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: PK3CB (P42338)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1)
Gene: PIK3CB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	7479742
Identification Methods	filter binding, coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1070
+	Hs
		128836 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		P3C2A_HUMAN (122-1066): 0: 830: 26.66
+	Hs
		128810 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		P3C2A_HUMAN (122-1066): 0: 830: 26.66
+	Hs
		128838 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		P3C2A_HUMAN (122-1066): 0: 830: 26.66
+	Hs
		128813 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		P3C2A_HUMAN (122-1066): 0: 830: 26.66
+	Hs
		135774 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		P3C2B_HUMAN (123-1066): 0: 814: 26.52
+	Hs
		135766 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		P3C2B_HUMAN (123-1066): 0: 814: 26.52
+	Hs
		135776 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		P3C2B_HUMAN (123-1066): 0: 814: 26.52
+	Hs
		135769 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		P3C2B_HUMAN (123-1066): 0: 814: 26.52
+	Hs
		128814 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		P3C2A_HUMAN (122-1066): 0: 830: 26.66
+	Hs
		135770 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		P3C2B_HUMAN (123-1066): 0: 814: 26.52
+	Dm
		664613 1433Z_DROME (1-245): 3.68e-141: 397: 77.14		Q7K3H0_DROME (267-1066): 0: 653: 28.50
+	Hs
		647121 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		PK3C3_HUMAN (303-1069): 1.96e-157: 491: 19.82
+	Hs
		927318 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		PK3C3_HUMAN (303-1069): 1.96e-157: 491: 19.82
+	Hs
		646792 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		PRKDC_HUMAN (496-1019): 2.59e-101: 354: 17.25
+	Hs
		926917 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		PRKDC_HUMAN (496-1019): 2.59e-101: 354: 17.25
+	Hs
		683261 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		PRKDC_HUMAN (496-1019): 2.59e-101: 354: 17.25
+	Hs
		910120 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		PI4KB_HUMAN (794-1057): 7.61e-81: 283: 28.46
+	Hs
		647352 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		PI4KB_HUMAN (794-1057): 7.61e-81: 283: 28.46
+	Hs
		927618 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		PI4KB_HUMAN (794-1057): 7.61e-81: 283: 28.46
+	Hs
		683785 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		PI4KB_HUMAN (794-1057): 7.61e-81: 283: 28.46