Protein: SMAD4
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (SMAD family member 4) (SMAD 4) (Smad4)

Gene: SMAD4
Organism: Mus musculus
Interactions: 41
UniProt ID: P97471

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001222 - transcription corepressor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1021510

SMAD3
Mothers against decapentaplegic homolog 3

8

18

Small-scale

0.958

High

1021506

SMAD2
Mothers against decapentaplegic homolog 2

6

18

Small-scale

0.935

High

1000222

SMAD1
Mothers against decapentaplegic homolog 1

2

19

Small-scale

0.737

High

1021503

SKI
Ski oncogene

1

16

Small-scale

0.665

High

1021455

SMAD5
Mothers against decapentaplegic homolog 5

1

19

Small-scale

0.618

High

1021495

SMAD4
Mothers against decapentaplegic homolog 4

1

18

Small-scale

0.618

High

1021498

GATA4
Transcription factor GATA-4

1

8

Small-scale

0.573

High

237252

TLX3
T-cell leukemia homeobox protein 3

1

11

High-throughput

0.541

High

946346

FOXP1
Forkhead box protein P1

1

10

High-throughput

0.541

High

697741

LEF1
Lymphoid enhancer-binding factor 1

1

20

Small-scale

0.515

High

1021502

FSHB
Follitropin subunit beta

1

2

Small-scale

0.515

High

900700

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

19

Small-scale

0.501

High

1021496

GATA5
Transcription factor GATA-5

1

8

Small-scale

0.501

High

1021504

GATA6
Transcription factor GATA-6

1

8

Small-scale

0.501

High

1021508

ERBIN
Erbin

1

10

Small-scale

0.501

High

871188

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

Small-scale

0.480

High

1021512

HOP
Homeodomain-only protein

1

0

Small-scale

0.479

High

59138

PRD16
Histone-lysine N-methyltransferase PRDM16

1

13

Small-scale

0.479

High

148675

HDAC1
Histone deacetylase 1

1

12

Small-scale

0.479

High

267135

PKNX1
Homeobox protein PKNOX1

1

11

Small-scale

0.479

High

465918

CO3A1

1

16

Small-scale

0.479

High

486817

CADH1
Cadherin-1

1

4

Small-scale

0.479

High

536203

CO1A1
Collagen alpha-1(I) chain

1

16

Small-scale

0.479

High

835787

PBX1
Pre-B-cell leukemia transcription factor 1

1

9

Small-scale

0.479

High

1021497

SNAI1
Zinc finger protein SNAI1

1

6

Small-scale

0.479

High

1021499

SF3B2
Splicing factor 3B subunit 2

1

5

Small-scale

0.479

High

1021500

FBW1A
F-box/WD repeat-containing protein 1A

1

5

Small-scale

0.479

High

1021501

SIN3A
Paired amphipathic helix protein Sin3a

1

1

Small-scale

0.479

High

1021505

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

8

Small-scale

0.479

High

1021507

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

3

Small-scale

0.479

High

1021509

Q8BTS0
Probable ATP-dependent RNA helicase DDX5

1

10

Small-scale

0.479

High

1021513

PEX6
Peroxisomal ATPase PEX6

1

5

Small-scale

0.479

High

1021514

ZMYM2
Zinc finger MYM-type protein 2

1

5

Small-scale

0.479

High

1021515

4ET
Eukaryotic translation initiation factor 4E transporter

1

4

Small-scale

0.479

High

148069

PAR3
Proteinase-activated receptor 3

1

3

Small-scale

0.457

High

505010

KGP1
cGMP-dependent protein kinase 1

1

14

Small-scale

0.445

High

1021516

GTF2I
General transcription factor II-I

1

3

Small-scale

0.445

High

312007

CO5A1

1

16

Small-scale

0.437

High

398340

CFAD
Complement factor D

1

2

High-throughput

0.437

High

1021511

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025