HitPredict

Interactor 1: PUR6 (P22234)
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)]
Gene: PAICS

Interactor 2: PUR6 (P22234)
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)]
Gene: PAICS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.951

The method score is based on:

Property Details
Experiments 25416956, 16189514, 16169070, 32296183, 21988832, unassigned1304
Identification Methods two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid, two hybrid pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains AIRC~AIRC, AIRC~SAICAR_synt, SAICAR_synt~SAICAR_synt
Common GO terms GO:0004638 - phosphoribosylaminoimidazole carboxylase activity
GO:0004639 - phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 8 others

more...
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 425
Hs

1 425
+ Dm
+ Ce
+ Ec
+ Cj
+ Sc
+ Ec

Service provided by Combinatics, Japan

Last updated: 11Aug2025