Protein: PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) (Protein adenosine-5) [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)]

Gene: PUR6, Paics
Organism: Drosophila melanogaster
Interactions: 194
UniProt ID: Q9I7S8

Gene Ontology (top 5):
GO:0004638 - phosphoribosylaminoimidazole carboxylase activity
GO:0004639 - phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1440560

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

6

High-throughput

0.656

High

1270104

TFP8L
Protein salivary glands marred

2

0

High-throughput

0.547

High

1440571

Q9VAC1
GM14349p

2

0

High-throughput

0.545

High

1440577

ATLAS
Atlastin

1

0

Small-scale

0.458

High

54036

A1Z892
1-Cys peroxiredoxin

1

1

High-throughput

0.445

High

57592

A1ZB71
Glutathione S transferase E6

1

1

High-throughput

0.445

High

121262

ALDR
Aldo-keto reductase 1B

1

4

High-throughput

0.445

High

197080

O18332
FI01544p

1

1

High-throughput

0.445

High

197347

O18335
Rab11

1

1

High-throughput

0.445

High

234761

O46067
Hypoxia up-regulated protein 1

1

1

High-throughput

0.445

High

611503

PSA4
Proteasome subunit alpha type-4

1

1

High-throughput

0.445

High

648912

ANXB9
Annexin B9

1

1

High-throughput

0.445

High

649073

ANX10
Annexin B10

1

1

High-throughput

0.445

High

726387

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

762581

UCHL
Ubiquitin carboxyl-terminal hydrolase

1

1

High-throughput

0.445

High

856061

MOEH
Moesin/ezrin/radixin homolog 1

1

1

High-throughput

0.445

High

871645

FKB12
Peptidyl-prolyl cis-trans isomerase Fkbp12

1

3

High-throughput

0.445

High

875248

TCPG
T-complex protein 1 subunit gamma

1

2

High-throughput

0.445

High

929520

PDI
Protein disulfide-isomerase

1

2

High-throughput

0.445

High

958881

ARF1
ADP-ribosylation factor 1

1

1

High-throughput

0.445

High

1019618

TRXR1
Thioredoxin reductase 1, mitochondrial

1

2

High-throughput

0.445

High

1031217

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.445

High

1052433

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.445

High

1176289

VATA2
V-type proton ATPase catalytic subunit A isoform 2

1

2

High-throughput

0.445

High

1176556

NLP
Nucleoplasmin-like protein

1

2

High-throughput

0.445

High

1262137

Q7JVH6
LD24696p

1

4

High-throughput

0.445

High

1262827

Q7JX87
1-Cys peroxiredoxin

1

1

High-throughput

0.445

High

1265802

Q7K3J0
T-complex protein 1 subunit theta

1

1

High-throughput

0.445

High

1267252

Q7KKI0
T-complex protein 1 subunit epsilon

1

2

High-throughput

0.445

High

1267913

TERA
Transitional endoplasmic reticulum ATPase TER94

1

1

High-throughput

0.445

High

1305722

Q8IQZ7
FI19014p1

1

2

High-throughput

0.445

High

1321962

Q8MYY7
RE44624p

1

2

High-throughput

0.445

High

1344412

Q8SYG3
E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.445

High

1376843

LDH
L-lactate dehydrogenase

1

1

High-throughput

0.445

High

1440564

Q9V3V6
26S proteasome regulatory complex subunit p50

1

3

High-throughput

0.445

High

1440566

THIO2
Thioredoxin-2

1

1

High-throughput

0.445

High

1440568

PSA3
Proteasome subunit alpha type-3

1

2

High-throughput

0.445

High

1440572

Q9VAC4
GEO09167p1

1

2

High-throughput

0.445

High

1440574

Q9VAN7
Phosphoglycerate mutase

1

1

High-throughput

0.445

High

1440575

Q9VAY2
Heat shock protein 83

1

4

High-throughput

0.445

High

1440581

Q9VEB1
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.445

High

1440582

FLNA
Filamin-A

1

1

High-throughput

0.445

High

1440589

Q9VHL2
T-complex protein 1 subunit eta

1

1

High-throughput

0.445

High

1440592

Q9VHX4
LD24679p

1

4

High-throughput

0.445

High

1440602

FKB59
FK506-binding protein 59

1

2

High-throughput

0.445

High

1440604

AK200
A-kinase anchor protein 200

1

1

High-throughput

0.445

High

1440605

SYAC
Alanine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.445

High

1440609

PSB4
Proteasome subunit beta type-4

1

2

High-throughput

0.445

High

1440611

Q9VPN5
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.445

High

1440616

Q9VQL1
serine--tRNA ligase

1

1

High-throughput

0.445

High

1440622

Q9VSL2
Glutathione S transferase O3

1

1

High-throughput

0.445

High

1440623

Q9VTY2
Uncharacterized protein, isoform A

1

4

High-throughput

0.445

High

1440625

Q9VUC1
Hsc70Cb, isoform A

1

3

High-throughput

0.445

High

1440635

Q9VXQ5
Chaperonin containing TCP1 subunit 6

1

1

High-throughput

0.445

High

1440636

CLIC
Chloride intracellular channel Clic

1

1

High-throughput

0.445

High

1440643

Q9W392
T-complex protein 1 subunit beta

1

2

High-throughput

0.445

High

1440651

PSB3
Proteasome subunit beta type-3

1

1

High-throughput

0.445

High

1440652

Q9XYZ9
Glutathione S transferase E12, isoform A

1

1

High-throughput

0.445

High

1440654

PSA6
Proteasome subunit alpha type-6

1

2

High-throughput

0.445

High

1440656

Q9Y112
BcDNA.GH10614

1

4

High-throughput

0.445

High

1440585

Q9VG69
LP03547p

1

1

High-throughput

0.437

High

57816

A1ZB77
Uncharacterized protein, isoform J

1

0

High-throughput

0.426

High

145974

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.426

High

195073

O16043
Anon1A4

1

0

High-throughput

0.426

High

234589

VINC
Vinculin

1

0

High-throughput

0.426

High

305683

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.426

High

357322

O97428
Ciboulot, isoform A

1

0

High-throughput

0.426

High

357543

INO1
Inositol-3-phosphate synthase

1

0

High-throughput

0.426

High

458112

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

0

High-throughput

0.426

High

460091

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.426

High

476979

NDKA
Nucleoside diphosphate kinase

1

0

High-throughput

0.426

High

556712

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.426

High

578111

ENO
Enolase

1

0

High-throughput

0.426

High

609427

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.426

High

632967

GLNA1
Glutamine synthetase 1, mitochondrial

1

0

High-throughput

0.426

High

682780

PROF
Profilin

1

0

High-throughput

0.426

High

821872

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.426

High

835162

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

0

High-throughput

0.426

High

874674

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.426

High

928997

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

0

High-throughput

0.426

High

1176718

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.426

High

1260827

Q76NR6
Regucalcin

1

0

High-throughput

0.426

High

1264120

Q7K0E6
Aspartate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

1264675

Q7K148
Proteasome subunit beta

1

0

High-throughput

0.426

High

1268077

Q7KN85
ATP-citrate synthase

1

0

High-throughput

0.426

High

1268251

Q7KN99
Phosphopantothenoylcysteine synthetase, isoform A

1

0

High-throughput

0.426

High

1269452

Q7KTW5
Inositol-1-monophosphatase

1

0

High-throughput

0.426

High

1303912

Q8INK3
Fatty acid-binding protein, muscle

1

0

High-throughput

0.426

High

1306100

Q8IRD3
Glutathione peroxidase

1

0

High-throughput

0.426

High

1321672

Q8MT58
Carnosine dipeptidase 2, isoform A

1

0

High-throughput

0.426

High

1343009

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

1

0

High-throughput

0.426

High

1343309

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.426

High

1345238

Q8T0L3
E1 ubiquitin-activating enzyme

1

0

High-throughput

0.426

High

1374515

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.426

High

1377635

FAXC
Failed axon connections

1

0

High-throughput

0.426

High

1427836

IF5A
Eukaryotic translation initiation factor 5A

1

0

High-throughput

0.426

High

1440023

JUPIT
Microtubule-associated protein Jupiter

1

0

High-throughput

0.426

High

1440561

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

1

0

High-throughput

0.426

High

1440562

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.426

High

1440569

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.426

High

1440578

Q9VCK6
LD34157p

1

0

High-throughput

0.426

High

1440579

Q9VD02
GH14779p

1

0

High-throughput

0.426

High

1440583

Q9VG31
Malic enzyme

1

0

High-throughput

0.426

High

1440587

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.426

High

1440588

TEBPH
Cytosolic Prostaglandin E synthase

1

0

High-throughput

0.426

High

1440590

Q9VHN7
transketolase

1

0

High-throughput

0.426

High

1440591

DPP3
Dipeptidyl peptidase 3

1

0

High-throughput

0.426

High

1440593

Q9VIE8
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.426

High

1440595

Q9VKB0
threonine--tRNA ligase

1

0

High-throughput

0.426

High

1440597

Q9VKW5
Prolyl endopeptidase

1

0

High-throughput

0.426

High

1440598

Q9VKZ8
Ubiquitin carboxyl-terminal hydrolase

1

0

High-throughput

0.426

High

1440599

EF1D
Probable elongation factor 1-delta

1

0

High-throughput

0.426

High

1440603

Q9VLB7
Rab GDP dissociation inhibitor

1

0

High-throughput

0.426

High

1440607

Q9VMV9
Reticulon-like protein

1

0

High-throughput

0.426

High

1440608

Q9VN44
FI07923p

1

0

High-throughput

0.426

High

1440612

COLD
UPAR/Ly6 domain-containing protein cold

1

0

High-throughput

0.426

High

1440613

Q9VPX6
Adenylyl cyclase-associated protein

1

0

High-throughput

0.426

High

1440618

Q9VRD6
NTF2-related export protein

1

0

High-throughput

0.426

High

1440619

Q9VRL1
GEO06356p1

1

0

High-throughput

0.426

High

1440621

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.426

High

1440624

Q9VU35
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.426

High

1440626

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.426

High

1440628

Y9705
Cold shock domain-containing protein CG9705

1

0

High-throughput

0.426

High

1440631

Q9VW59
Rho GDP-dissociation inhibitor 3

1

0

High-throughput

0.426

High

1440639

Q9W0E4
Aminopeptidase

1

0

High-throughput

0.426

High

1440640

Q9W0H8
Reticulocalbin-3

1

0

High-throughput

0.426

High

1440641

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.426

High

1440642

Q9W227
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.426

High

1440646

Q9W3Y3
Calcyclin-binding protein

1

0

High-throughput

0.426

High

1440648

WUHO
tRNA

1

0

High-throughput

0.426

High

1440649

Q9W457
Serine hydroxymethyltransferase

1

0

High-throughput

0.426

High

1440653

Q9XZ57
Eb1, isoform E

1

0

High-throughput

0.426

High

1440655

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.426

High

663984

PHB1
Prohibitin 1

1

2

High-throughput

0.407

High

1191670

Q3YMU0
Protein disulfide-isomerase

1

1

High-throughput

0.407

High

1261542

Q7JR58
Probable enoyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.407

High

1440563

Q9V3V2
peptidylprolyl isomerase

1

3

High-throughput

0.407

High

1440567

PDIA6
Protein disulfide-isomerase A6 homolog

1

1

High-throughput

0.407

High

1440580

Q9VD29
small monomeric GTPase

1

4

High-throughput

0.407

High

1440586

Q9VGK3
peptidylprolyl isomerase

1

3

High-throughput

0.407

High

1440600

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

1

2

High-throughput

0.407

High

1440629

Q9VVL7
Dihydrolipoyl dehydrogenase

1

2

High-throughput

0.407

High

1440633

Q9VWL0
Mec2

1

1

High-throughput

0.407

High

1440637

Q9VZI1
Transgelin

1

1

High-throughput

0.407

High

1440638

Q9W022
GEO01508p1

1

2

High-throughput

0.407

High

1440645

Q9W3X6
fumarate hydratase

1

1

High-throughput

0.407

High

1440647

CISY
Probable citrate synthase, mitochondrial

1

1

High-throughput

0.407

High

1440565

Q9V3V9
Endonuclease G inhibitor, isoform A

3

0

High-throughput

0.334

High

1440630

Q9VVT4
IP10578p

2

0

High-throughput

0.310

High

1304753

Q8IPU8
BNIP3, isoform B

1

0

High-throughput

0.253

Low

827989

MEF2
Myocyte-specific enhancer factor 2

1

0

High-throughput

0.249

Low

86527

B9EQV3
Endoplasmic reticulum transmembrane protein

1

0

High-throughput

0.232

Low

197811

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.232

Low

304659

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.232

Low

305222

TRMB
tRNA

1

0

High-throughput

0.232

Low

356385

O97102
Small ubiquitin-related modifier

1

0

High-throughput

0.232

Low

426723

HP1
Heterochromatin protein 1

1

0

High-throughput

0.232

Low

712376

CALR
Calreticulin

1

0

High-throughput

0.232

Low

715130

CLH
Clathrin heavy chain

1

0

High-throughput

0.232

Low

930167

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.232

Low

1026639

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.232

Low

1052247

HMGD
High mobility group protein D

1

0

High-throughput

0.232

Low

1070776

Q0KHZ6
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.232

Low

1173557

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.232

Low

1174227

ATPO
ATP synthase subunit O, mitochondrial

1

0

High-throughput

0.232

Low

1262676

Q7JWV7
Tetraspanin

1

0

High-throughput

0.232

Low

1263011

Q7JXC4
CG6459 protein

1

0

High-throughput

0.232

Low

1264517

Q7K110
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.232

Low

1265255

Q7K2K2
FI04612p

1

0

High-throughput

0.232

Low

1267385

Q7KLX3
Translocon-associated protein subunit delta

1

0

High-throughput

0.232

Low

1268160

Q7KN94
Electron transfer flavoprotein subunit alpha

1

0

High-throughput

0.232

Low

1374378

Q94513
Boundary element associated factor

1

0

Small-scale

0.232

Low

1374663

ACPM
Acyl carrier protein, mitochondrial

1

0

High-throughput

0.232

Low

1375305

VDAC
Voltage-dependent anion-selective channel

1

0

High-throughput

0.232

Low

1440121

NASP
Nuclear autoantigenic sperm protein homolog

1

0

High-throughput

0.232

Low

1440570

Q9V9U3
LD45254p

1

0

High-throughput

0.232

Low

1440573

CISD2
CDGSH iron-sulfur domain protein

1

0

High-throughput

0.232

Low

1440576

Q9VBR6
RE74917p

1

0

High-throughput

0.232

Low

1440584

Q9VG33
Sulfurtransferase

1

0

High-throughput

0.232

Low

1440594

Q9VJ59
PRA1 family protein

1

0

High-throughput

0.232

Low

1440596

Q9VKM7
AT01533p

1

0

High-throughput

0.232

Low

1440601

Q9VL70
HL08109p

1

0

High-throughput

0.232

Low

1440606

Q9VMU6
LD31822p

1

0

High-throughput

0.232

Low

1440610

Q9VNB2
RE42193p

1

0

High-throughput

0.232

Low

1440614

Q9VQ61
Aspartate aminotransferase

1

0

High-throughput

0.232

Low

1440615

BACC
Bacchus

1

0

High-throughput

0.232

Low

1440617

Q9VQL7
Fatty acid synthase

1

0

High-throughput

0.232

Low

1440620

Q9VRP2
Uncharacterized protein, isoform A

1

0

High-throughput

0.232

Low

1440627

Q9VUZ0
Translocon-associated protein subunit beta

1

0

High-throughput

0.232

Low

1440632

RS10B
Small ribosomal subunit protein eS10B

1

0

High-throughput

0.232

Low

1440634

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.232

Low

1440644

Q9W3N1
RH59310p

1

0

High-throughput

0.232

Low

1440650

Q9W478
RE43153p

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025