HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: M3K20 (Q9NYL2)
Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)
Gene: MAP3K20

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	33961781, 36931259, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 800
+	Hs
		910094 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		M3K20_HUMAN (1-800): 0: 1246: 100.00
+	At
		965327 14332_ARATH (3-243): 8.65e-144: 404: 61.22		PBS1_ARATH (2-359): 2.99e-132: 403: 19.07
+	At
		965320 14332_ARATH (3-243): 8.65e-144: 404: 61.22		BAK1_ARATH (1-262): 4.62e-126: 392: 21.84
+	At
		1277300 14337_ARATH (2-243): 2.78e-142: 400: 60.32		SERK1_ARATH (1-305): 6.82e-126: 392: 19.94
+	Hs
		909438 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		M3K9_HUMAN (7-326): 7.7e-116: 378: 38.91
+	Hs
		909462 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		M3K10_HUMAN (10-326): 2.28e-116: 376: 38.66
+	Hs
		646793 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		M3K9_HUMAN (7-326): 7.7e-116: 378: 38.91
+	Hs
		926918 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		M3K9_HUMAN (7-326): 7.7e-116: 378: 38.91
+	Hs
		646816 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		M3K10_HUMAN (10-326): 2.28e-116: 376: 38.66
+	Hs
		926946 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		M3K10_HUMAN (10-326): 2.28e-116: 376: 38.66
+	Hs
		909655 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		M3K21_HUMAN (9-326): 1.09e-109: 360: 36.70
+	Hs
		927089 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		M3K11_HUMAN (12-331): 1.29e-112: 364: 37.01
+	Hs
		646976 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		M3K21_HUMAN (9-326): 1.09e-109: 360: 36.70
+	Hs
		789053 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ABL2_HUMAN (9-338): 3.12e-105: 351: 30.50
+	Hs
		646706 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		ABL2_HUMAN (9-338): 3.12e-105: 351: 30.50
+	Hs
		789056 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		ABL2_HUMAN (9-338): 3.12e-105: 351: 30.50
+	Hs
		337416 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ABL1_HUMAN (3-343): 1.65e-99: 335: 26.85
+	Hs
		646845 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		M3K12_HUMAN (7-331): 7.44e-103: 338: 37.02
+	Hs
		337355 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		ABL1_HUMAN (3-343): 1.65e-99: 335: 26.85
+	Hs
		337420 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		ABL1_HUMAN (3-343): 1.65e-99: 335: 26.85