Protein: PCSK9
Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9)

Gene: PCSK9
Organism: Homo sapiens
Interactions: 76
UniProt ID: Q8NBP7

Gene Ontology (top 5):
GO:0001822 - kidney development
GO:0001889 - liver development
GO:0001920 - negative regulation of receptor recycling
GO:0002091 - negative regulation of receptor internalization
GO:0002092 - positive regulation of receptor internalization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

376527

LDLR
Low-density lipoprotein receptor

5

1

Small-scale

0.924

High

168433

NCTR3
Natural cytotoxicity triggering receptor 3

1

3

High-throughput

0.691

High

841569

I12R1
Interleukin-12 receptor subunit beta-1

1

2

High-throughput

0.691

High

1147380

EPHA7
Ephrin type-A receptor 7

1

1

High-throughput

0.691

High

1236108

FSTL4
Follistatin-related protein 4

1

2

High-throughput

0.691

High

1333884

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

13

Small-scale

0.647

High

1107430

BIRC2
Baculoviral IAP repeat-containing protein 2

1

1

Small-scale

0.578

High

399458

TRGV3
T cell receptor gamma variable 3

1

2

High-throughput

0.575

High

469689

MMP2
72 kDa type IV collagenase

1

4

Small-scale

0.568

High

1312558

FA20C
Extracellular serine/threonine protein kinase FAM20C

2

0

Small-scale

0.547

High

154854

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

1

High-throughput

0.536

High

164773

GDF8
Growth/differentiation factor 8

1

3

High-throughput

0.536

High

224505

PI15
Peptidase inhibitor 15

1

3

High-throughput

0.536

High

268930

FCG3B
Low affinity immunoglobulin gamma Fc region receptor III-B

1

2

High-throughput

0.536

High

273775

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

1

High-throughput

0.536

High

289327

FCN3
Ficolin-3

1

3

High-throughput

0.536

High

342624

LY86
Lymphocyte antigen 86

1

2

High-throughput

0.536

High

388728

C1QB
Complement C1q subcomponent subunit B

1

5

High-throughput

0.536

High

426117

PPB1
Alkaline phosphatase, placental type

1

1

High-throughput

0.536

High

561377

TDGF1
Protein Cripto

1

2

High-throughput

0.536

High

567922

PRG2
Bone marrow proteoglycan

1

6

High-throughput

0.536

High

570698

EDN3
Endothelin-3

1

1

High-throughput

0.536

High

593442

PGFRA
Platelet-derived growth factor receptor alpha

1

1

High-throughput

0.536

High

597805

CRIS2
Cysteine-rich secretory protein 2

1

3

High-throughput

0.536

High

628428

KLK2
Kallikrein-2

1

7

High-throughput

0.536

High

647385

IDS
Iduronate 2-sulfatase

1

1

High-throughput

0.536

High

945900

INHBE
Inhibin beta E chain

1

3

High-throughput

0.536

High

1030194

IL5RA
Interleukin-5 receptor subunit alpha

1

5

High-throughput

0.536

High

1116250

PTC1
Protein patched homolog 1

1

2

High-throughput

0.536

High

1248563

LYPD4
Ly6/PLAUR domain-containing protein 4

1

1

High-throughput

0.536

High

1248773

LYZL1
Lysozyme-like protein 1

1

1

High-throughput

0.536

High

1333741

TM87A
Transmembrane protein 87A

1

1

High-throughput

0.536

High

1333885

FIBIN
Fin bud initiation factor homolog

1

1

High-throughput

0.536

High

1333887

CA054
Uncharacterized protein C1orf54

1

2

High-throughput

0.536

High

1333888

GGH
Gamma-glutamyl hydrolase

1

2

High-throughput

0.536

High

1333889

ESPB1
Epididymal sperm-binding protein 1

1

2

High-throughput

0.536

High

1333894

SDF2L
Stromal cell-derived factor 2-like protein 1

1

3

High-throughput

0.536

High

1333895

CBLN4
Cerebellin-4

1

5

High-throughput

0.536

High

1333900

PRG3
Proteoglycan 3

1

5

High-throughput

0.536

High

1333901

ADA18
Disintegrin and metalloproteinase domain-containing protein 18

1

2

High-throughput

0.536

High

942347

BACE1
Beta-secretase 1

1

0

Small-scale

0.513

High

327073

NXPH3
Neurexophilin-3

1

0

High-throughput

0.513

High

656018

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.513

High

880039

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.513

High

1179111

TECT1
Tectonic-1

1

0

High-throughput

0.513

High

1333886

CLC4C
C-type lectin domain family 4 member C

1

0

High-throughput

0.513

High

456799

ANXA2
Annexin A2

1

0

Small-scale

0.512

High

1333892

SC11C
Signal peptidase complex catalytic subunit SEC11C

1

0

High-throughput

0.493

High

86010

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

4

High-throughput

0.489

High

1160419

TAZ
Tafazzin

1

1

High-throughput

0.489

High

130170

PGRC1
Membrane-associated progesterone receptor component 1

1

1

Small-scale

0.479

High

170875

CLGN
Calmegin

1

2

Small-scale

0.479

High

218479

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

258987

DNJA2
DnaJ homolog subfamily A member 2

1

6

Small-scale

0.479

High

566760

PDIA4
Protein disulfide-isomerase A4

1

3

Small-scale

0.479

High

727887

DNJA1
DnaJ homolog subfamily A member 1

1

6

Small-scale

0.479

High

1090799

TRAF2
TNF receptor-associated factor 2

1

1

Small-scale

0.479

High

1145621

RCN1
Reticulocalbin-1

1

1

Small-scale

0.479

High

1199805

AGK
Acylglycerol kinase, mitochondrial

1

1

Small-scale

0.479

High

1312013

DJC10
DnaJ homolog subfamily C member 10

1

7

Small-scale

0.479

High

1333890

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

4

Small-scale

0.479

High

1333891

TBB6
Tubulin beta-6 chain

1

2

Small-scale

0.479

High

1333897

DJB11
DnaJ homolog subfamily B member 11

1

4

Small-scale

0.479

High

1333899

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

Small-scale

0.479

High

162239

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

Small-scale

0.458

High

415735

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.458

High

859906

RL28
Large ribosomal subunit protein eL28

1

0

Small-scale

0.458

High

1333896

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

Small-scale

0.458

High

292177

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

4

Small-scale

0.437

High

916303

TXTP
Tricarboxylate transport protein, mitochondrial

1

4

Small-scale

0.437

High

1312320

MIRO1
Mitochondrial Rho GTPase 1

1

3

Small-scale

0.437

High

1333898

DIC
Mitochondrial dicarboxylate carrier

1

6

Small-scale

0.437

High

222305

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.426

High

1239244

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

1333893

DPEP2
Dipeptidase 2

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025