HitPredict

Interactor 1: AP2B (P27351)
AP-2 complex subunit beta (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Clathrin assembly protein large beta chain)
Gene: APL1

Interactor 2: AP2A (P38065)
AP-2 complex subunit alpha (Alpha-adaptin) (Clathrin assembly protein complex 2 alpha large chain) (Clathrin assembly protein large alpha chain)
Gene: APL3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	11805826, 19822444, 37968396, 16429126
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adaptin_N~Adaptin_N
Common GO terms	GO:0005935 - cellular bud neck GO:0006886 - intracellular protein transport GO:0030122 - AP-2 adaptor complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 700 Sc			1 1025
+	Hs
		321523 AP2B1_HUMAN (1-699): 0: 583: 27.89		AP2A1_HUMAN (11-1023): 0: 676: 21.52
+	Mm
		567513 AP2B1_MOUSE (1-699): 0: 583: 27.89		AP2A1_MOUSE (11-1023): 0: 674: 21.71
+	Hs
		302132 AP2B1_HUMAN (1-699): 0: 583: 27.89		AP2A2_HUMAN (11-1023): 0: 673: 22.10
+	Hs
		321535 AP1B1_HUMAN (1-700): 0: 556: 26.69		AP2A1_HUMAN (11-1023): 0: 676: 21.52
+	Hs
		302144 AP1B1_HUMAN (1-700): 0: 556: 26.69		AP2A2_HUMAN (11-1023): 0: 673: 22.10
+	Dm
		954826 Q24253_DROME (1-634): 0: 548: 28.64		AP2A_DROME (12-1023): 0: 653: 23.00
+	At
		286690 APBLC_ARATH (3-700): 0: 559: 28.10		AP2A1_ARATH (17-1023): 0: 600: 21.74
+	At
		1228260 APBLB_ARATH (3-699): 0: 553: 27.71		AP2A1_ARATH (17-1023): 0: 600: 21.74
+	Hs
		212616 AP2B1_HUMAN (1-699): 0: 583: 27.89		AP1G1_HUMAN (21-876): 0: 570: 18.76
+	Hs
		925858 AP2B1_HUMAN (1-699): 0: 583: 27.89		AP1B1_HUMAN (43-1017): 8.29e-179: 547: 11.88
+	Hs
		212624 AP1B1_HUMAN (1-700): 0: 556: 26.69		AP1G1_HUMAN (21-876): 0: 570: 18.76
+	Hs
		276363 AP2B1_HUMAN (1-699): 0: 583: 27.89		AP1G2_HUMAN (22-872): 1.49e-169: 518: 17.57
+	Hs
		276366 AP1B1_HUMAN (1-700): 0: 556: 26.69		AP1G2_HUMAN (22-872): 1.49e-169: 518: 17.57
+	Hs
		1353981 COPG2_HUMAN (2-698): 1.54e-161: 489: 13.34		COPG2_HUMAN (29-1015): 0: 556: 10.85
+	Hs
		1353995 COPG2_HUMAN (2-698): 1.54e-161: 489: 13.34		COPG1_HUMAN (29-1015): 1.45e-176: 539: 11.15
+	Hs
		1014041 AP1B1_HUMAN (1-700): 0: 556: 26.69		Q86V28_HUMAN (234-872): 6.22e-131: 412: 17.25