Protein: THIC
Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Acetyl-CoA transferase-like protein) (Cytosolic acetoacetyl-CoA thiolase)

Gene: THIC, ACAT2
Organism: Homo sapiens
Interactions: 56
UniProt ID: Q9BWD1

Gene Ontology (top 5):
GO:0003985 - acetyl-CoA C-acetyltransferase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006629 - lipid metabolic process
GO:0006631 - fatty acid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1416059

THIC
Acetyl-CoA acetyltransferase, cytosolic

2

12

High-throughput

0.791

High

666353

THIL
Acetyl-CoA acetyltransferase, mitochondrial

2

12

High-throughput

0.776

High

1348475

LNX1
E3 ubiquitin-protein ligase LNX

2

1

High-throughput

0.628

High

1415152

LST8
Target of rapamycin complex subunit LST8

2

4

High-throughput

0.611

High

1416065

WWOX
WW domain-containing oxidoreductase

2

3

High-throughput

0.606

High

783749

ZNF76
Zinc finger protein 76

2

1

High-throughput

0.553

High

928542

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.549

High

1416060

TX101
Testis-expressed protein 101

1

1

High-throughput

0.489

High

728411

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

High-throughput

0.481

High

208559

PJA2
E3 ubiquitin-protein ligase Praja-2

1

3

Small-scale

0.479

High

242795

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

380132

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.479

High

508549

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.479

High

641001

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

1

High-throughput

0.479

High

659578

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

872700

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

1094971

TRAF3
TNF receptor-associated factor 3

1

2

Small-scale

0.479

High

1209610

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.479

High

1255364

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1334864

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1364572

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1416067

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1416068

TNIK
TRAF2 and NCK-interacting protein kinase

1

4

High-throughput

0.479

High

1416071

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.479

High

1416072

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.479

High

347911

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

989781

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

0

High-throughput

0.458

High

1007653

CCNA1
Cyclin-A1

1

0

High-throughput

0.458

High

1405477

S10AD
Protein S100-A13

1

0

High-throughput

0.458

High

1416061

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

1416066

TRM7
tRNA

1

0

High-throughput

0.458

High

1416070

TPPC8
Trafficking protein particle complex subunit 8

1

0

High-throughput

0.458

High

142407

PEX7
Peroxisomal targeting signal 2 receptor

1

11

High-throughput

0.445

High

530318

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

935086

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.445

High

1391031

OTUB1
Ubiquitin thioesterase OTUB1

1

1

High-throughput

0.445

High

1416063

ITM2C
Integral membrane protein 2C

1

2

High-throughput

0.445

High

1416064

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.445

High

1416069

GAB2
GRB2-associated-binding protein 2

1

4

High-throughput

0.445

High

254643

EIF1B
Eukaryotic translation initiation factor 1b

1

3

High-throughput

0.437

High

373042

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.437

High

412547

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

589591

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

696401

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

769071

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

598767

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

1029148

E2F1
Transcription factor E2F1

1

0

High-throughput

0.426

High

689852

CD27
CD27 antigen

1

1

High-throughput

0.407

High

1416062

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.279

Low

176087

KDM6B
Lysine-specific demethylase 6B

1

0

Small-scale

0.249

Low

941539

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.249

Low

50036

F170A
Protein FAM170A

1

0

High-throughput

0.232

Low

330299

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

1349106

F174A
Membrane protein FAM174A

1

0

High-throughput

0.232

Low

1416073

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025