Protein: THIM
3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1)

Gene: THIM, ACAA2
Organism: Homo sapiens
Interactions: 102
UniProt ID: P42765

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003985 - acetyl-CoA C-acetyltransferase activity
GO:0003986 - acetyl-CoA hydrolase activity
GO:0003988 - acetyl-CoA C-acyltransferase activity
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

842211

PPCEL
Prolyl endopeptidase-like

3

1

High-throughput

0.667

High

842233

TR61B
tRNA

3

2

High-throughput

0.656

High

842206

SYLM
Leucine--tRNA ligase, mitochondrial

2

1

High-throughput

0.628

High

842191

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

2

0

High-throughput

0.585

High

240990

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

842209

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

842230

MGME1
Mitochondrial genome maintenance exonuclease 1

2

0

High-throughput

0.576

High

322211

GLSK
Glutaminase kidney isoform, mitochondrial

1

3

High-throughput

0.536

High

539299

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

3

High-throughput

0.536

High

554784

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

4

High-throughput

0.536

High

725588

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

2

High-throughput

0.536

High

842194

SYHM
Histidine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

842201

CDK18
Cyclin-dependent kinase 18

1

3

High-throughput

0.536

High

842202

CP24A
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

1

1

High-throughput

0.536

High

842210

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

1

2

High-throughput

0.536

High

842213

SYAM
Alanine--tRNA ligase, mitochondrial

1

3

High-throughput

0.536

High

842217

ACD10
Acyl-CoA dehydrogenase family member 10

1

2

High-throughput

0.536

High

842219

SYDM
Aspartate--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

842226

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

1

High-throughput

0.536

High

842228

SYNM
Asparaginyl-tRNA synthetase

1

1

High-throughput

0.536

High

842229

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

1

High-throughput

0.536

High

842232

TMM70
Transmembrane protein 70, mitochondrial

1

1

High-throughput

0.536

High

842234

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

High-throughput

0.536

High

842188

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

2

6

High-throughput

0.533

High

842189

CACP
Carnitine O-acetyltransferase

1

0

High-throughput

0.513

High

842195

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.513

High

842197

DPOG1
DNA polymerase subunit gamma-1

1

0

High-throughput

0.513

High

842198

KIME
Mevalonate kinase

1

0

High-throughput

0.513

High

842200

FOLC
Folylpolyglutamate synthase, mitochondrial

1

0

High-throughput

0.513

High

842223

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

842238

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.513

High

842247

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.513

High

842255

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

842257

PUS1
Pseudouridylate synthase 1 homolog

1

0

High-throughput

0.513

High

127646

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

1

High-throughput

0.489

High

132576

UPK1A
Uroplakin-1a

1

1

High-throughput

0.489

High

302771

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

7

High-throughput

0.489

High

622772

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

2

High-throughput

0.489

High

720962

CLIP1
CAP-Gly domain-containing linker protein 1

1

3

High-throughput

0.489

High

842239

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

2

High-throughput

0.489

High

208474

PJA2
E3 ubiquitin-protein ligase Praja-2

1

3

Small-scale

0.479

High

371392

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

411527

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.479

High

443248

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

532428

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.479

High

629627

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

842190

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

842199

TLE2
Transducin-like enhancer protein 2

1

5

High-throughput

0.479

High

842203

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

842207

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

842216

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

842246

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

3

High-throughput

0.479

High

842250

HDAC6
Protein deacetylase HDAC6

1

4

High-throughput

0.479

High

842208

HSPB2
Heat shock protein beta-2

1

1

High-throughput

0.464

High

162918

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.460

High

477944

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.460

High

842243

ZFYV1
Zinc finger FYVE domain-containing protein 1

1

0

Small-scale

0.458

High

842253

TES
Testin

1

0

High-throughput

0.458

High

421663

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.457

High

529277

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

842205

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

5

Small-scale

0.445

High

842220

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

1

Small-scale

0.445

High

842244

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.445

High

842245

S39A9
Zinc transporter ZIP9

1

2

High-throughput

0.445

High

227163

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

4

Small-scale

0.439

High

142884

NFIB
Nuclear factor 1 B-type

1

1

High-throughput

0.437

High

157054

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.437

High

227415

SPOP
Speckle-type POZ protein

1

2

High-throughput

0.437

High

473843

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.437

High

583831

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

3

Small-scale

0.437

High

606377

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.437

High

842193

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.437

High

842204

CUL1
Cullin-1

1

5

Small-scale

0.437

High

842214

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

1

6

Small-scale

0.437

High

842221

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

842222

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

Small-scale

0.437

High

842224

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.437

High

842240

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

842241

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.437

High

842242

WDR76
WD repeat-containing protein 76

1

11

High-throughput

0.437

High

842248

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.437

High

842252

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.437

High

842256

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

1

High-throughput

0.437

High

598542

UD2B7
UDP-glucuronosyltransferase 2B7

1

1

Small-scale

0.407

High

842212

S39AC
Zinc transporter ZIP12

1

2

High-throughput

0.407

High

842235

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

1

High-throughput

0.407

High

842237

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

842249

VGLU2
Vesicular glutamate transporter 2

1

1

High-throughput

0.407

High

219138

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.282

High

842192

PCP4
Calmodulin regulator protein PCP4

1

0

High-throughput

0.279

Low

842218

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

842225

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

842227

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

842236

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.279

Low

600486

ZNF3
Zinc finger protein 3

1

0

High-throughput

0.249

Low

842196

CO4A4

1

0

High-throughput

0.249

Low

842231

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.249

Low

47906

S12A8
Solute carrier family 12 member 8

1

0

High-throughput

0.232

Low

842187

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.232

Low

842215

SL9C2
Sodium/hydrogen exchanger 11

1

0

High-throughput

0.232

Low

842251

TRI10
Tripartite motif-containing protein 10

1

0

High-throughput

0.232

Low

842254

S22AD
Solute carrier family 22 member 13

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025