Protein: MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)

Gene: MKNK2
Organism: Homo sapiens
Interactions: 53
UniProt ID: Q9HBH9

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calmodulin-dependent protein kinase activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1082639

MK14
Mitogen-activated protein kinase 14

7

20

Small-scale

0.970

High

659061

MK01
Mitogen-activated protein kinase 1

5

20

Small-scale

0.931

High

803756

BAG6
Large proline-rich protein BAG6

2

11

High-throughput

0.802

High

800833

MK08
Mitogen-activated protein kinase 8

1

20

High-throughput

0.698

High

647686

MK03
Mitogen-activated protein kinase 3

1

20

High-throughput

0.691

High

703441

CSTF2
Cleavage stimulation factor subunit 2

1

1

High-throughput

0.691

High

835526

GSK3A
Glycogen synthase kinase-3 alpha

1

13

High-throughput

0.691

High

836007

GSK3B
Glycogen synthase kinase-3 beta

1

19

High-throughput

0.691

High

1020571

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.691

High

1230045

RPTOR
Regulatory-associated protein of mTOR

1

7

High-throughput

0.691

High

1312694

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

18

High-throughput

0.691

High

1314624

RBM4
RNA-binding protein 4

1

3

High-throughput

0.691

High

158037

KLF11
Krueppel-like factor 11

1

2

High-throughput

0.665

High

1272105

CELF1
CUGBP Elav-like family member 1

1

0

High-throughput

0.656

High

1130610

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.647

High

1302054

SRPK1
SRSF protein kinase 1

1

17

High-throughput

0.647

High

637565

PSA1
Proteasome subunit alpha type-1

2

2

High-throughput

0.606

High

1335456

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

16

High-throughput

0.590

High

979998

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

7

Small-scale

0.561

High

772167

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.552

High

125722

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.536

High

171843

WDR46
WD repeat-containing protein 46

1

1

High-throughput

0.536

High

382153

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

High-throughput

0.536

High

535942

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.536

High

575853

VINC
Vinculin

1

2

High-throughput

0.536

High

1061069

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

2

High-throughput

0.536

High

1131605

ZMYM1
Zinc finger MYM-type protein 1

1

4

High-throughput

0.536

High

1135222

RBM26
RNA-binding protein 26

1

3

High-throughput

0.536

High

1139521

TUT7
Terminal uridylyltransferase 7

1

2

High-throughput

0.536

High

1185265

RFIP2
Rab11 family-interacting protein 2

1

6

High-throughput

0.536

High

1198840

ADCK1
AarF domain-containing protein kinase 1

1

1

High-throughput

0.536

High

1273077

FUBP2
Far upstream element-binding protein 2

1

3

High-throughput

0.536

High

913771

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.518

High

215042

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.513

High

1271067

SYMPK
Symplekin

1

0

High-throughput

0.513

High

1319428

BHE41
Class E basic helix-loop-helix protein 41

1

0

High-throughput

0.513

High

1335457

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

High-throughput

0.513

High

417028

IF4E
Eukaryotic translation initiation factor 4E

1

3

Small-scale

0.501

High

850501

PLXA3
Plexin-A3

1

1

High-throughput

0.489

High

1163867

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.489

High

1240425

TXND5
Thioredoxin domain-containing protein 5

1

2

High-throughput

0.489

High

1041470

CUL2
Cullin-2

1

5

Small-scale

0.481

High

1269662

ESR2
Estrogen receptor beta

1

8

Small-scale

0.481

High

1043601

CUL4B
Cullin-4B

1

5

High-throughput

0.479

High

901743

PFD3
Prefoldin subunit 3

1

0

Small-scale

0.460

High

921435

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.460

High

1058398

MESD
LRP chaperone MESD

2

0

High-throughput

0.316

High

238022

EXOC3
Exocyst complex component 3

1

0

High-throughput

0.279

Low

1216106

TCAM1
TIR domain-containing adapter molecule 1

1

0

High-throughput

0.279

Low

1254110

C99L2
CD99 antigen-like protein 2

1

0

High-throughput

0.279

Low

1288999

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.279

Low

1306924

HAUS7
HAUS augmin-like complex subunit 7

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024