Protein: THIL
Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2)

Gene: THIL, ACAT1
Organism: Homo sapiens
Interactions: 182
UniProt ID: P24752

Gene Ontology (top 5):
GO:0001889 - liver development
GO:0003985 - acetyl-CoA C-acetyltransferase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

666353

THIC
Acetyl-CoA acetyltransferase, cytosolic

2

12

High-throughput

0.776

High

470856

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

3

3

Small-scale

0.674

High

240782

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.624

High

666291

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

6

High-throughput

0.618

High

371189

MYC
Myc proto-oncogene protein

3

4

Small-scale

0.585

High

279655

CISY
Citrate synthase, mitochondrial

2

4

High-throughput

0.584

High

666289

CUL3
Cullin-3

2

5

High-throughput

0.584

High

666303

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

666374

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

1

Small-scale

0.578

High

619500

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.576

High

666252

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

12

Small-scale

0.575

High

457237

TBB5
Tubulin beta chain

2

1

High-throughput

0.571

High

666269

TERA
Transitional endoplasmic reticulum ATPase

2

5

High-throughput

0.571

High

666352

TR61B
tRNA

2

2

High-throughput

0.571

High

657486

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.537

High

217251

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

2

High-throughput

0.536

High

361117

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

666257

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.536

High

666280

KPCZ
Protein kinase C zeta type

1

3

High-throughput

0.536

High

666346

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

3

High-throughput

0.536

High

666304

RHG44
Rho GTPase-activating protein 44

2

1

High-throughput

0.521

High

666327

RHG24
Rho GTPase-activating protein 24

2

2

High-throughput

0.521

High

666328

SH2D3
SH2 domain-containing protein 3C

2

1

High-throughput

0.521

High

666330

DOCK8
Dedicator of cytokinesis protein 8

2

1

High-throughput

0.521

High

352976

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.515

High

474487

VIME
Vimentin

1

0

High-throughput

0.493

High

666325

DLP1
All trans-polyprenyl-diphosphate synthase PDSS2

1

0

High-throughput

0.493

High

213815

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

3

High-throughput

0.489

High

666258

PSB10
Proteasome subunit beta type-10

1

2

High-throughput

0.489

High

666294

FAK2
Protein-tyrosine kinase 2-beta

1

2

High-throughput

0.489

High

666301

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.489

High

666321

HEAT3
HEAT repeat-containing protein 3

1

1

High-throughput

0.489

High

142282

PEX7
Peroxisomal targeting signal 2 receptor

1

11

Small-scale

0.481

High

522594

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

1

Small-scale

0.481

High

125244

LEG9
Galectin-9

1

1

High-throughput

0.479

High

276062

NIPS2
Protein NipSnap homolog 2

1

1

Small-scale

0.479

High

281885

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

287240

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

319409

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

379878

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.479

High

400294

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

411375

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.479

High

520746

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.479

High

532370

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

587942

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

666256

LONM
Lon protease homolog, mitochondrial

1

6

High-throughput

0.479

High

666259

MDHM
Malate dehydrogenase, mitochondrial

1

3

High-throughput

0.479

High

666262

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

6

High-throughput

0.479

High

666264

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

666270

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.479

High

666276

RHOB
Rho-related GTP-binding protein RhoB

1

5

High-throughput

0.479

High

666277

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.479

High

666278

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.479

High

666281

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

666283

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

666284

GRSF1
G-rich sequence factor 1

1

1

High-throughput

0.479

High

666285

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

4

High-throughput

0.479

High

666300

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

666306

SYAM
Alanine--tRNA ligase, mitochondrial

1

3

High-throughput

0.479

High

666311

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

666313

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

666316

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

2

High-throughput

0.479

High

666320

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

5

High-throughput

0.479

High

666323

TAXB1
Tax1-binding protein 1

1

4

High-throughput

0.479

High

666329

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

666333

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

666334

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.479

High

666336

FAKD4
FAST kinase domain-containing protein 4

1

5

High-throughput

0.479

High

666337

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

666338

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

666341

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

666342

RCC1L
RCC1-like G exchanging factor-like protein

1

1

High-throughput

0.479

High

666345

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

666350

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.479

High

666351

TMM70
Transmembrane protein 70, mitochondrial

1

1

High-throughput

0.479

High

666354

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

666355

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

666357

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

666358

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

666360

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

666361

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

666364

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

2

High-throughput

0.479

High

666369

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

3

High-throughput

0.479

High

666371

AKIP
Small ribosomal subunit protein mS38

1

1

High-throughput

0.479

High

666372

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

5

High-throughput

0.479

High

666376

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

666378

TNIK
TRAF2 and NCK-interacting protein kinase

1

4

High-throughput

0.479

High

666379

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

Small-scale

0.479

High

254525

EIF1B
Eukaryotic translation initiation factor 1b

1

3

High-throughput

0.470

High

61427

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

66131

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

183589

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

259456

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

345384

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

350791

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

361604

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

519050

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

536525

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

565155

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

666254

3MG
DNA-3-methyladenine glycosylase

1

0

High-throughput

0.458

High

666261

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

666263

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

666267

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

666273

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

666279

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

666282

QOR
Quinone oxidoreductase

1

0

High-throughput

0.458

High

666293

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

666302

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.458

High

666314

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

666339

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

666349

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

666356

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

666359

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

666363

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

666370

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

666373

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

666375

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

666381

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

666344

LMTK3
Serine/threonine-protein kinase LMTK3

1

14

High-throughput

0.457

High

529106

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

666274

RHOA
Transforming protein RhoA

1

5

High-throughput

0.445

High

666298

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

5

Small-scale

0.445

High

666312

PKHA7
Pleckstrin homology domain-containing family A member 7

1

10

High-throughput

0.445

High

666340

OTUB1
Ubiquitin thioesterase OTUB1

1

1

High-throughput

0.445

High

666368

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.445

High

666382

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

1

High-throughput

0.445

High

105364

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

156969

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.437

High

227376

SPOP
Speckle-type POZ protein

1

2

High-throughput

0.437

High

293218

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

315131

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.437

High

606241

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.437

High

659355

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.437

High

666253

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

666255

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

666260

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

666265

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.437

High

666266

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

666272

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.437

High

666275

WDR5
WD repeat-containing protein 5

1

6

High-throughput

0.437

High

666286

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

666287

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

5

High-throughput

0.437

High

666288

CUL1
Cullin-1

1

5

High-throughput

0.437

High

666290

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.437

High

666295

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

666297

CUL7
Cullin-7

1

1

High-throughput

0.437

High

666299

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

666307

ARHGG
Rho guanine nucleotide exchange factor 16

1

1

High-throughput

0.437

High

666308

TET5C
Terminal nucleotidyltransferase 5C

1

1

High-throughput

0.437

High

666309

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.437

High

666317

RHG36
Rho GTPase-activating protein 36

1

3

High-throughput

0.437

High

666318

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

666319

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.437

High

666324

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.437

High

666326

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.437

High

666332

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.437

High

666335

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.437

High

666362

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

666365

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.437

High

666366

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.437

High

666367

FBX6
F-box only protein 6

1

1

High-throughput

0.437

High

666377

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.437

High

666380

HDAC5
Histone deacetylase 5

1

4

High-throughput

0.437

High

924

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.426

High

397898

ANGI
Angiogenin

1

0

High-throughput

0.426

High

666271

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

6

High-throughput

0.407

High

666292

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.407

High

666322

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

0

High-throughput

0.279

Low

638833

AGT1
Alanine--glyoxylate aminotransferase

1

0

High-throughput

0.251

Low

238391

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.249

Low

377174

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

666268

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.249

Low

666296

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.249

Low

666310

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

666331

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

666347

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

0

High-throughput

0.249

Low

666348

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.249

Low

354542

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.232

Low

666305

KLH22
Kelch-like protein 22

1

0

High-throughput

0.232

Low

666315

ZNT10
Calcium/manganese antiporter SLC30A10

1

0

High-throughput

0.232

Low

666343

SMIP9
Protein SPMIP9

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025