Protein: HSDL2
Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-) (Short chain dehydrogenase/reductase family 13C member 1)

Gene: HSDL2
Organism: Homo sapiens
Interactions: 128
UniProt ID: Q6YN16

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005777 - peroxisome
GO:0016020 - membrane
GO:0016491 - oxidoreductase activity
GO:0042632 - cholesterol homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

242051

PRKN
E3 ubiquitin-protein ligase parkin

3

4

High-throughput

0.640

High

342925

HERC2
E3 ubiquitin-protein ligase HERC2

2

5

High-throughput

0.628

High

471096

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

2

5

High-throughput

0.611

High

1251581

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

4

High-throughput

0.611

High

1251592

NEUL4
Neuralized-like protein 4

2

0

High-throughput

0.602

High

1251595

MIPEP
Mitochondrial intermediate peptidase

2

0

High-throughput

0.602

High

445928

ENOA
Alpha-enolase

2

1

High-throughput

0.601

High

279804

CISY
Citrate synthase, mitochondrial

2

2

High-throughput

0.584

High

896258

PEX5
Peroxisomal targeting signal 1 receptor

2

8

Small-scale

0.584

High

1162387

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

5

High-throughput

0.584

High

936074

PAR2
Proteinase-activated receptor 2

2

4

High-throughput

0.574

High

484572

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

3

High-throughput

0.536

High

776975

PPM1A
Protein phosphatase 1A

1

1

High-throughput

0.536

High

788073

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

1251615

NPS3A
Protein NipSnap homolog 3A

1

2

High-throughput

0.536

High

436688

KPCB
Protein kinase C beta type

2

2

High-throughput

0.521

High

278683

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.513

High

822153

PSB10
Proteasome subunit beta type-10

1

4

High-throughput

0.489

High

1161118

MK06
Mitogen-activated protein kinase 6

1

4

High-throughput

0.489

High

61534

VWA8
von Willebrand factor A domain-containing protein 8

1

3

High-throughput

0.479

High

122512

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

5

High-throughput

0.479

High

275047

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

2

High-throughput

0.479

High

281987

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

287315

RF1M
Peptide chain release factor 1, mitochondrial

1

1

High-throughput

0.479

High

315709

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

350906

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

374010

RASN
GTPase NRas

1

6

High-throughput

0.479

High

399986

CATA
Catalase

1

5

High-throughput

0.479

High

404144

GCR
Glucocorticoid receptor

1

10

High-throughput

0.479

High

458436

ADRB2
Beta-2 adrenergic receptor

1

7

High-throughput

0.479

High

532694

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.479

High

786143

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.479

High

828818

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

856296

IF2M
Translation initiation factor IF-2, mitochondrial

1

4

High-throughput

0.479

High

867224

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.479

High

984169

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.479

High

986511

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

1058095

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1083648

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

1090442

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.479

High

1117763

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

6

High-throughput

0.479

High

1138331

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1142577

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

1207051

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1240292

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

1251577

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

1

High-throughput

0.479

High

1251579

CNTRL
Centriolin

1

1

High-throughput

0.479

High

1251586

ESR2
Estrogen receptor beta

1

10

High-throughput

0.479

High

1251587

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

1251590

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

1251591

MTEF3
Transcription termination factor 3, mitochondrial

1

1

High-throughput

0.479

High

1251594

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

1251597

TMM70
Transmembrane protein 70, mitochondrial

1

1

High-throughput

0.479

High

1251600

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

1251606

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

3

High-throughput

0.479

High

1251616

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

1

High-throughput

0.479

High

1251621

FND3A
Fibronectin type-III domain-containing protein 3A

1

2

High-throughput

0.479

High

184304

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

319855

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

519145

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

841798

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

851930

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

882737

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

1024082

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1048566

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1123325

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

1234425

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1251589

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

1251596

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1251598

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

1251599

TR61B
tRNA

1

0

High-throughput

0.458

High

1251601

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1251602

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1251605

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1251609

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

0

Small-scale

0.458

High

1251611

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1251613

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

1251614

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

142357

PEX7
Peroxisomal targeting signal 2 receptor

1

8

High-throughput

0.445

High

653394

HEMH
Ferrochelatase, mitochondrial

1

3

High-throughput

0.445

High

1209298

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

1251610

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.445

High

331070

KI20A
Kinesin-like protein KIF20A

1

9

High-throughput

0.437

High

588977

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

695762

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

768486

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

879207

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

962188

RHOA
Transforming protein RhoA

1

9

High-throughput

0.437

High

965043

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.437

High

1015540

RHOG
Rho-related GTP-binding protein RhoG

1

7

High-throughput

0.437

High

1106970

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.437

High

1122516

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

High-throughput

0.437

High

1228423

FTM
Protein fantom

1

2

High-throughput

0.437

High

1238717

TECT3
Tectonic-3

1

4

High-throughput

0.437

High

1248957

LMBRL
Protein LMBR1L

1

3

High-throughput

0.437

High

1251576

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.437

High

1251578

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1251583

NUP43
Nucleoporin Nup43

1

10

High-throughput

0.437

High

1251584

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.437

High

1251588

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

3

High-throughput

0.437

High

1251593

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.437

High

1251603

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

1251604

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.437

High

1251607

ANLN
Anillin

1

2

High-throughput

0.437

High

1251612

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

1251617

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.437

High

1251620

FBW1A
F-box/WD repeat-containing protein 1A

1

5

High-throughput

0.437

High

1251623

KIF3A
Kinesin-like protein KIF3A

1

3

High-throughput

0.437

High

1251624

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

1251618

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

0

High-throughput

0.426

High

116976

J3KPF9
Kinesin-like protein

1

3

High-throughput

0.407

High

328051

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

High-throughput

0.407

High

374699

RASH
GTPase HRas

1

6

High-throughput

0.407

High

430059

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

730699

1433S
14-3-3 protein sigma

1

1

High-throughput

0.407

High

1234834

PKHA7
Pleckstrin homology domain-containing family A member 7

1

11

High-throughput

0.407

High

692727

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

954510

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.279

Low

1109832

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.279

Low

1251580

LHPL4
LHFPL tetraspan subfamily member 4 protein

1

0

High-throughput

0.279

Low

1251582

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

927034

ATX3
Ataxin-3

1

0

Small-scale

0.249

Low

1104911

XRCC4
DNA repair protein XRCC4

1

0

High-throughput

0.249

Low

1251585

DNJC9
DnaJ homolog subfamily C member 9

1

0

High-throughput

0.249

Low

1251608

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

1251619

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.249

Low

1251622

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

598747

ANFB
Natriuretic peptides B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025