HitPredict

Interactor 1: P121C (A8CG34)
Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C)
Gene: POM121C

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21182203
Identification Methods	cosedimentation through density gradient
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1229 Hs			1 530
+	Hs
		1269354 P121A_HUMAN (1-1229): 8.01e-79: 286: 93.69		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1270066 PCLO_HUMAN (33-1156): 4.02e-35: 148: 9.33		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1056909 MDC1_HUMAN (80-893): 2.1e-29: 129: 10.92		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1269843 YM012_HUMAN (510-1065): 5.13e-28: 122: 14.72		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		554348 MUC1_HUMAN (47-509): 1.16e-20: 100: 11.64		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369607 MDC1_HUMAN (80-893): 2.1e-29: 129: 10.92		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		1269591 TARA_HUMAN (68-1198): 1.61e-14: 81.3: 10.04		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		368927 MUC1_HUMAN (47-509): 1.16e-20: 100: 11.64		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370417 TARA_HUMAN (68-1198): 1.61e-14: 81.3: 10.04		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370263 MINT_HUMAN (1-1187): 3.89e-14: 80.1: 9.85		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369612 NCOA6_HUMAN (359-1228): 9.06e-13: 75.3: 9.95		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Mm
		1142304 HCFC1_MOUSE (124-1210): 3.44e-26: 119: 10.84		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Dm
		558435 Q86BH2_DROME (84-1220): 7.47e-18: 92.2: 10.09		7UP1_DROME (17-502): 7.37e-106: 329: 22.67
+	Hs
		782596 ARI1B_HUMAN (129-1213): 3.55e-15: 83.3: 9.44		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		377505 ARI1B_HUMAN (129-1213): 3.55e-15: 83.3: 9.44		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		377537 MUC16_HUMAN (5-1214): 1.08e-14: 81.8: 10.41		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		782640 MINT_HUMAN (1-1187): 3.89e-14: 80.1: 9.85		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		377624 MINT_HUMAN (1-1187): 3.89e-14: 80.1: 9.85		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		487431 MDC1_HUMAN (80-893): 2.1e-29: 129: 10.92		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487598 ARI1B_HUMAN (129-1213): 3.55e-15: 83.3: 9.44		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59