HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: PK3CB (Q8BTI9)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1)
Gene: Pik3cb

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	27474268
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 913 Mm			1 1064
+	Hs
		651205 CBL_HUMAN (1-913): 0: 870: 90.83		PK3CB_HUMAN (1-1064): 0: 1291: 95.87
+	Mm
		205658 CBL_MOUSE (1-913): 0: 900: 100.00		PK3CD_MOUSE (1-1063): 0: 1194: 54.98
+	Mm
		651488 CBL_MOUSE (1-913): 0: 900: 100.00		PK3CA_MOUSE (1-1061): 0: 1052: 38.92
+	Hs
		651204 CBL_HUMAN (1-913): 0: 870: 90.83		PK3CA_HUMAN (1-1061): 0: 1060: 39.11
+	Mm
		651579 CBL_MOUSE (1-913): 0: 900: 100.00		PK3CG_MOUSE (1-1058): 0: 1012: 31.58
+	Hs
		1195659 HUWE1_HUMAN (435-884): 3.99e-12: 73: 17.38		Q4LE69_HUMAN (442-1052): 3.33e-145: 481: 20.80
+	Hs
		1008214 HUWE1_HUMAN (435-884): 3.99e-12: 73: 17.38		PRKDC_HUMAN (507-1020): 1.06e-96: 340: 17.67
+	Hs
		1008148 MDC1_HUMAN (430-908): 1.52e-11: 70.7: 10.89		PRKDC_HUMAN (507-1020): 1.06e-96: 340: 17.67