Protein: PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1)

Gene: PK3CB, PIK3CB
Organism: Homo sapiens
Interactions: 86
UniProt ID: P42338

Gene Ontology (top 5):
GO:0001935 - endothelial cell proliferation
GO:0001952 - regulation of cell-matrix adhesion
GO:0002931 - response to ischemia
GO:0003376 - sphingosine-1-phosphate receptor signaling pathway
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

699628

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

12

20

Small-scale

0.981

High

136322

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

8

20

Small-scale

0.973

High

839168

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

6

20

Small-scale

0.939

High

839144

GRB2
Growth factor receptor-bound protein 2

3

20

High-throughput

0.871

High

839136

CRK
Adapter molecule crk

3

18

High-throughput

0.817

High

839165

HAVR2
Hepatitis A virus cellular receptor 2

2

2

High-throughput

0.811

High

137499

BT3A1
Butyrophilin subfamily 3 member A1

1

3

High-throughput

0.691

High

839137

CRKL
Crk-like protein

1

17

High-throughput

0.691

High

788860

TGFR2
TGF-beta receptor type-2

3

1

High-throughput

0.667

High

839135

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

9

High-throughput

0.667

High

839140

EFNB2
Ephrin-B2

3

5

High-throughput

0.667

High

839155

PCBP1
Poly(rC)-binding protein 1

3

2

High-throughput

0.667

High

483836

CD7
T-cell antigen CD7

1

0

High-throughput

0.656

High

651205

CBL
E3 ubiquitin-protein ligase CBL

3

8

Small-scale

0.656

High

839141

RAB5B
Ras-related protein Rab-5B

1

15

Small-scale

0.647

High

362918

EGFR
Epidermal growth factor receptor

3

20

Small-scale

0.640

High

630141

ACM3
Muscarinic acetylcholine receptor M3

2

8

High-throughput

0.628

High

749757

CADH5
Cadherin-5

2

2

High-throughput

0.628

High

839163

RN19B
E3 ubiquitin-protein ligase RNF19B

2

7

High-throughput

0.628

High

839167

RPGF5
Rap guanine nucleotide exchange factor 5

2

2

High-throughput

0.628

High

839175

DOCK5
Dedicator of cytokinesis protein 5

2

1

High-throughput

0.628

High

839181

NLGN3
Neuroligin-3

2

1

High-throughput

0.628

High

839182

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

2

3

High-throughput

0.628

High

839186

I20RA
Interleukin-20 receptor subunit alpha

2

6

High-throughput

0.628

High

375261

RASK
GTPase KRas

1

20

High-throughput

0.618

High

631098

RAB5A
Ras-related protein Rab-5A

1

17

Small-scale

0.618

High

839176

WDR26
WD repeat-containing protein 26

1

10

Small-scale

0.618

High

839185

SEPT9
Septin-9

2

1

High-throughput

0.601

High

772469

IRS1
Insulin receptor substrate 1

2

8

Small-scale

0.584

High

839161

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.575

High

839159

TM52B
Transmembrane protein 52B

2

1

High-throughput

0.574

High

839166

ZDHC1
Palmitoyltransferase ZDHHC1

2

8

High-throughput

0.574

High

839178

MANS1
MANSC domain-containing protein 1

2

1

High-throughput

0.574

High

839184

CCG5
Voltage-dependent calcium channel gamma-5 subunit

2

2

High-throughput

0.574

High

669111

ARBK1
Beta-adrenergic receptor kinase 1

1

12

Small-scale

0.561

High

690808

1433T
14-3-3 protein theta

1

20

Small-scale

0.561

High

133231

P2Y10
Putative P2Y purinoceptor 10

1

20

High-throughput

0.536

High

160436

IRS4
Insulin receptor substrate 4

1

7

High-throughput

0.536

High

641508

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.536

High

839139

V1BR
Vasopressin V1b receptor

1

14

High-throughput

0.536

High

839142

CXCR4
C-X-C chemokine receptor type 4

1

15

High-throughput

0.536

High

839146

CAV1
Caveolin-1

1

1

High-throughput

0.536

High

839150

TP53B
TP53-binding protein 1

1

3

High-throughput

0.536

High

839162

KLD10
Kelch domain-containing protein 10

1

4

High-throughput

0.536

High

839171

TMM74
Transmembrane protein 74

1

2

High-throughput

0.536

High

839172

FEM1A
Protein fem-1 homolog A

1

4

High-throughput

0.536

High

839173

GTPB4
GTP-binding protein 4

1

1

High-throughput

0.536

High

839183

HCST
Hematopoietic cell signal transducer

1

1

High-throughput

0.536

High

839190

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

552767

TPR
Nucleoprotein TPR

1

11

High-throughput

0.515

High

421658

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.515

High

191300

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.513

High

583930

KCNE1
Potassium voltage-gated channel subfamily E member 1

1

0

High-throughput

0.513

High

839138

GLYG
Glycogenin-1

1

0

High-throughput

0.513

High

839156

SF3A2
Splicing factor 3A subunit 2

1

0

High-throughput

0.513

High

839177

NOL11
Nucleolar protein 11

1

0

High-throughput

0.513

High

839180

SSF1
Suppressor of SWI4 1 homolog

1

0

High-throughput

0.513

High

839169

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

2

High-throughput

0.508

High

839160

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

Small-scale

0.501

High

410686

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.500

High

839157

AINX
Alpha-internexin

1

3

High-throughput

0.489

High

560836

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

0

High-throughput

0.486

High

839164

HPS6
BLOC-2 complex member HPS6

1

0

High-throughput

0.486

High

157052

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

169994

AURKA
Aurora kinase A

1

10

High-throughput

0.479

High

262033

NBN
Nibrin

1

3

Small-scale

0.479

High

411521

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

540343

LAMP1
Lysosome-associated membrane glycoprotein 1

1

3

High-throughput

0.479

High

728085

AKT1
RAC-alpha serine/threonine-protein kinase

1

9

High-throughput

0.479

High

839143

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

3

Small-scale

0.479

High

839145

KPCE
Protein kinase C epsilon type

1

5

Small-scale

0.479

High

839147

KPCD
Protein kinase C delta type

1

8

Small-scale

0.479

High

839149

TFCP2
Alpha-globin transcription factor CP2

1

2

High-throughput

0.479

High

839152

SMAD4
Mothers against decapentaplegic homolog 4

1

2

High-throughput

0.479

High

839153

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.479

High

839154

EEA1
Early endosome antigen 1

1

9

High-throughput

0.479

High

839158

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.479

High

839174

LPAR5
Lysophosphatidic acid receptor 5

1

20

Small-scale

0.479

High

839179

ECT2
Protein ECT2

1

10

High-throughput

0.479

High

839187

XPO7
Exportin-7

1

3

High-throughput

0.479

High

839188

ALK
ALK tyrosine kinase receptor

1

20

Small-scale

0.479

High

839189

GAB2
GRB2-associated-binding protein 2

1

6

Small-scale

0.479

High

484075

PGFRB
Platelet-derived growth factor receptor beta

1

20

High-throughput

0.445

High

839148

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.445

High

839151

PAK1
Serine/threonine-protein kinase PAK 1

1

7

Small-scale

0.445

High

839170

SPTCS
Spatacsin

1

0

Small-scale

0.438

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025