HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: RBBP6 (Q7Z6E9)
E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis)
Gene: RBBP6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37827155
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006260 - DNA replication GO:0006974 - DNA damage response
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 1792
+	Hs
		652037 RFA1_HUMAN (1-616): 0: 781: 100.00		MINT_HUMAN (76-1784): 4.28e-28: 126: 7.98
+	Hs
		651208 RFA1_HUMAN (1-616): 0: 781: 100.00		MDC1_HUMAN (508-1516): 4.61e-24: 113: 10.37
+	Hs
		651728 RFA1_HUMAN (1-616): 0: 781: 100.00		BD1L1_HUMAN (851-1782): 4.77e-20: 100: 13.46
+	Hs
		651725 RFA1_HUMAN (1-616): 0: 781: 100.00		KMT2C_HUMAN (88-1775): 2.2e-16: 88.1: 7.78
+	Hs
		651810 RFA1_HUMAN (1-616): 0: 781: 100.00		ELYS_HUMAN (577-1779): 2.2e-15: 84.9: 12.70
+	Hs
		651461 RFA1_HUMAN (1-616): 0: 781: 100.00		NIPBL_HUMAN (880-1382): 5.38e-11: 70.3: 18.50
+	Hs
		230311 RFA1_HUMAN (1-616): 0: 781: 100.00		ZC3H1_HUMAN (679-1650): 2.57e-10: 68: 12.68
+	Dm
		1097979 RFA1_DROME (1-614): 0: 619: 41.00		Q9VLS7_DROME (382-1689): 4.6e-21: 103: 7.43
+	Hs
		1056865 RADX_HUMAN (27-384): 6.8e-66: 233: 16.24		MDC1_HUMAN (508-1516): 4.61e-24: 113: 10.37