HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: EPHA3 (P29320)
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Gene: EPHA3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:1903078 - positive regulation of protein localization to plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 983
+	Hs
		655284 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA5_HUMAN (7-983): 0: 1202: 65.97
+	Hs
		655380 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA7_HUMAN (6-979): 0: 1198: 61.46
+	Hs
		655222 P85A_HUMAN (1-724): 0: 596: 100.00		EPHB2_HUMAN (29-981): 0: 1167: 55.90
+	Hs
		655285 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA4_HUMAN (8-983): 0: 1164: 62.40
+	Hs
		655221 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA8_HUMAN (29-982): 0: 1099: 56.57
+	Hs
		655219 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA2_HUMAN (27-983): 0: 1061: 50.47
+	Mm
		936453 P70304_MOUSE (1-724): 0: 591: 95.86		EPHA2_MOUSE (27-983): 0: 1036: 50.47
+	Hs
		600513 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA1_HUMAN (7-973): 0: 949: 42.52
+	Hs
		171288 P85A_HUMAN (1-724): 0: 596: 100.00		EPHB6_HUMAN (29-969): 0: 906: 39.84
+	Hs
		655230 P85A_HUMAN (1-724): 0: 596: 100.00		UFO_HUMAN (265-962): 1.06e-153: 479: 22.82
+	Mm
		643079 P85A_MOUSE (1-724): 0: 592: 95.99		UFO_MOUSE (265-962): 4.64e-153: 477: 22.55
+	Mm
		643093 P85A_MOUSE (1-724): 0: 592: 95.99		MERTK_MOUSE (267-935): 5.92e-150: 472: 21.77
+	Hs
		435546 P85A_HUMAN (1-724): 0: 596: 100.00		IGF1R_HUMAN (366-883): 1.6e-139: 453: 30.02
+	Hs
		655328 P85A_HUMAN (1-724): 0: 596: 100.00		TYRO3_HUMAN (289-882): 5.83e-141: 445: 23.41
+	Hs
		411306 P85A_HUMAN (1-724): 0: 596: 100.00		INSR_HUMAN (375-880): 6.57e-136: 444: 30.32
+	Mm
		546262 P85A_MOUSE (1-724): 0: 592: 95.99		INSR_MOUSE (377-880): 1.81e-134: 440: 30.25
+	Hs
		442782 P85A_HUMAN (1-724): 0: 596: 100.00		HCK_HUMAN (599-879): 3.57e-65: 230: 42.40
+	Hs
		412033 P85A_HUMAN (1-724): 0: 596: 100.00		FYN_HUMAN (615-879): 1.08e-64: 229: 44.20
+	Mm
		411918 P85A_MOUSE (1-724): 0: 592: 95.99		LCK_MOUSE (599-879): 1.81e-64: 228: 42.76
+	Mm
		643066 P85A_MOUSE (1-724): 0: 592: 95.99		FYN_MOUSE (615-879): 3.46e-64: 228: 43.82