HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: SHB (Q15464)
SH2 domain-containing adapter protein B
Gene: SHB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	7537362
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~SH2
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 509
+	Hs
		655429 P85A_HUMAN (1-724): 0: 596: 100.00		SHC3_HUMAN (16-507): 3.95e-75: 249: 16.82
+	Hs
		655224 P85A_HUMAN (1-724): 0: 596: 100.00		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Mm
		643078 P85A_MOUSE (1-724): 0: 592: 95.99		SHC1_MOUSE (105-508): 5.58e-66: 225: 17.12
+	Hs
		522796 P85A_HUMAN (1-724): 0: 596: 100.00		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		442782 P85A_HUMAN (1-724): 0: 596: 100.00		HCK_HUMAN (261-507): 1.14e-54: 193: 15.75
+	Hs
		433263 P85A_HUMAN (1-724): 0: 596: 100.00		YES_HUMAN (252-488): 8.79e-54: 191: 17.21
+	Hs
		557615 P85A_HUMAN (1-724): 0: 596: 100.00		NCK1_HUMAN (157-504): 3.1e-55: 191: 14.25
+	Hs
		412033 P85A_HUMAN (1-724): 0: 596: 100.00		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Mm
		643066 P85A_MOUSE (1-724): 0: 592: 95.99		FYN_MOUSE (283-506): 1.94e-53: 190: 15.16
+	Hs
		655306 P85A_HUMAN (1-724): 0: 596: 100.00		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		655254 P85A_HUMAN (1-724): 0: 596: 100.00		ABL2_HUMAN (354-487): 6.99e-36: 144: 26.12
+	Hs
		337356 P85A_HUMAN (1-724): 0: 596: 100.00		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03
+	Hs
		69202 P85A_HUMAN (1-724): 0: 596: 100.00		A9UF07_HUMAN (354-507): 2.39e-34: 140: 24.03
+	Hs
		129212 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		129185 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		129173 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		HCK_HUMAN (261-507): 1.14e-54: 193: 15.75
+	Hs
		129164 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Hs
		129269 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		129151 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03
+	Hs
		69198 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		A9UF07_HUMAN (354-507): 2.39e-34: 140: 24.03