HitPredict

Interactor 1: GATA3 (P23771)
Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3)
Gene: GATA3

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 443 Hs			1 197
+	Hs
		662558 GATA3_HUMAN (1-443): 2.53e-176: 502: 100.00		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		662559 GATA3_HUMAN (1-443): 2.53e-176: 502: 100.00		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		662407 GATA2_HUMAN (1-443): 3.17e-135: 399: 61.24		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Hs
		662405 GATA2_HUMAN (1-443): 3.17e-135: 399: 61.24		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		662406 GATA2_HUMAN (1-443): 3.17e-135: 399: 61.24		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		662411 GATA2_HUMAN (1-443): 3.17e-135: 399: 61.24		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Hs
		1048122 TRPS1_HUMAN (139-433): 2.18e-73: 252: 24.10		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		590407 GATA1_HUMAN (186-443): 1.67e-60: 204: 40.56		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		590408 GATA1_HUMAN (186-443): 1.67e-60: 204: 40.56		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		590414 GATA1_HUMAN (186-443): 1.67e-60: 204: 40.56		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00