HitPredict

Interactor 1: RPB1 (P24928)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: POLR2A

Interactor 2: RPAB3 (P52434)
DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (DNA-directed RNA polymerase II subunit H) (DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide) (RPB17) (RPB8 homolog) (hRPB8)
Gene: POLR2H

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.964

The method score is based on:

Property Details
Experiments 9201987, 37682711, 26414014, 19240132, 30349055, 24981860, 35271311, 17283126
Identification Methods pull down, affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains RNA_pol_Rpb1_3~RNA_pol_Rpb8, RNA_pol_Rpb1_4~RNA_pol_Rpb8, RNA_pol_Rpb1_5~RNA_pol_Rpb8
Common GO terms GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005665 - RNA polymerase II, core complex
GO:0006366 - transcription by RNA polymerase II
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 1970
Hs

1 150
+ Bt
+ Sp
+ Sc
+ Hs
+ Sc
+ Sc
+ At
+ Hs
+ Hs
+ At

Service provided by Combinatics, Japan

Last updated: 11Aug2025