HitPredict

Interactor 1: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1

Interactor 2: IL18 (Q14116)
Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
Gene: IL18

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	12096920, 9121587, 9334240, 15326478, 22270365
Identification Methods	enzymatic study, protease assay, anti tag coimmunoprecipitation
Interaction Type	direct interaction, cleavage reaction, physical association, protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0050729 - positive regulation of inflammatory response GO:0071222 - cellular response to lipopolysaccharide
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 404 Hs			1 193
+	Hs
		830278 CASP4_HUMAN (1-404): 6.94e-153: 438: 48.40		IL18_HUMAN (1-193): 3.83e-117: 331: 100.00
+	Hs
		851074 CASP5_HUMAN (5-404): 1.04e-145: 422: 46.25		IL18_HUMAN (1-193): 3.83e-117: 331: 100.00
+	Hs
		788197 CASP3_HUMAN (119-401): 3.4e-96: 290: 25.00		IL18_HUMAN (1-193): 3.83e-117: 331: 100.00