HitPredict

Interactor 1: RPB1 (P08775)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: Polr2a

Interactor 2: SMCA4 (Q3TKT4)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1)
Gene: Smarca4

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15999204
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RNA_pol_Rpb1_1~SNF2-rel_dom
Common GO terms	GO:0000791 - euchromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006366 - transcription by RNA polymerase II
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1970 Mm			1 1613
+	Hs
		667219 RPB1_HUMAN (1-1611): 0: 1902: 100.00		SMCA4_HUMAN (1-1613): 0: 1064: 97.21
+	Hs
		667218 RPB1_HUMAN (1-1611): 0: 1902: 100.00		SMCA2_HUMAN (40-1613): 0: 978: 73.50
+	Hs
		667465 RPB1_HUMAN (1-1611): 0: 1902: 100.00		CHD8_HUMAN (10-1482): 0: 709: 20.76
+	Sc
		401937 RPB1_YEAST (11-1599): 0: 1626: 49.31		STH1_YEAST (1167-1532): 4.56e-24: 112: 15.41
+	Sc
		402204 RPC1_YEAST (11-1474): 0: 1361: 32.71		STH1_YEAST (1167-1532): 4.56e-24: 112: 15.41
+	Sc
		534237 RPA1_YEAST (11-1472): 0: 1145: 22.86		STH1_YEAST (1167-1532): 4.56e-24: 112: 15.41
+	Dm
		402258 RPB1_DROME (1576-1967): 3.93e-22: 106: 50.76		BRM_DROME (213-1612): 0: 848: 55.06
+	Hs
		243494 RPA1_HUMAN (914-1476): 3.05e-39: 163: 16.25		SMCA5_HUMAN (595-1604): 0: 774: 27.31