HitPredict

Interactor 1: RPB1 (P24928)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: POLR2A

Interactor 2: SMCA4 (P51532)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1)
Gene: SMARCA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.860

Property	Details
Experiments	11238380, 8895581, 9845365, 15999204
Identification Methods	biochemical, affinity chromatography technology
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	RNA_pol_Rpb1_1~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016787 - hydrolase activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1970 Hs			1 1647
+	Mm
		476221 RPB1_MOUSE (1-1611): 0: 1900: 100.00		SMCA4_MOUSE (1-1647): 0: 1050: 96.66
+	Hs
		667218 RPB1_HUMAN (1-1611): 0: 1900: 100.00		SMCA2_HUMAN (40-1647): 0: 958: 72.59
+	Hs
		667465 RPB1_HUMAN (1-1611): 0: 1900: 100.00		CHD8_HUMAN (17-1527): 0: 714: 20.24
+	Sc
		401937 RPB1_YEAST (11-1593): 0: 1604: 49.00		STH1_YEAST (539-1563): 0: 740: 36.33
+	Sc
		402204 RPC1_YEAST (11-1471): 0: 1348: 32.98		STH1_YEAST (539-1563): 0: 740: 36.33
+	Sc
		534237 RPA1_YEAST (11-1472): 0: 1128: 23.04		STH1_YEAST (539-1563): 0: 740: 36.33
+	Hs
		243494 RPA1_HUMAN (1000-1476): 1.86e-34: 147: 16.93		SMCA5_HUMAN (594-1622): 0: 815: 27.27
+	Dm
		402258 RPB1_DROME (1692-1966): 1.58e-11: 72.3: 39.80		BRM_DROME (211-1643): 0: 844: 53.24