HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: CDK7 (P50613)
Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
Gene: CDK7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.982

The method score is based on:

Property Details
Experiments 8692842, 16191191, 10393546, 7629134, 15282296, 23064645, 16327805, 11113184, 15530371, 25852190, 8647086, 23455922
Identification Methods enzymatic study, affinity chromatography technology, protein kinase assay, tandem affinity purification
Interaction Type direct interaction, physical association, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0001673 - male germ cell nucleus
GO:0004674 - protein serine/threonine kinase activity
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005524 - ATP binding
and 7 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 298
Hs

1 346
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+ Mm
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Last updated: 11Aug2025