HitPredict

Interactor 1: PML (P29590)
Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19)
Gene: PML

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34795231, 36880596
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0008270 - zinc ion binding GO:0016925 - protein sumoylation GO:0019789 - SUMO transferase activity
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 882 Hs			1 628
+	Hs
		277945 PML_HUMAN (1-882): 0: 902: 100.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278232 PML_HUMAN (1-882): 0: 902: 100.00		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		668825 PML_HUMAN (1-882): 0: 902: 100.00		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Hs
		1318360 TRIM8_HUMAN (51-553): 2.61e-68: 239: 14.68		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		278162 TRIM5_HUMAN (44-459): 3.78e-58: 209: 12.33		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		170420 TIF1A_HUMAN (27-546): 1.94e-62: 231: 16.49		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Hs
		1030009 TIF1B_HUMAN (7-593): 6.89e-69: 247: 13.97		ZMIZ1_HUMAN (79-422): 1.82e-84: 287: 24.93