HitPredict

Interactor 1: PSMD3 (P25161)
Probable 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome subunit S3) (Diphenol oxidase A2 component) (DOX-A2) (Regulatory particle non-ATPase 3)
Gene: Rpn3

Interactor 2: Q7KMQ0 (Q7KMQ0)
26S proteasome regulatory subunit 7 (Proteasome 26S subunit ATPase 2)
Gene: Rpt1

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005838 - proteasome regulatory particle GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 494 Dm			1 433
+	Hs
		210877 PSMD3_HUMAN (4-494): 0: 578: 57.81		PRS7_HUMAN (1-433): 1e-143: 418: 91.69
+	Dm
		198023 PSMD3_DROME (1-494): 0: 600: 100.00		PRS8_DROME (50-430): 1.96e-123: 366: 48.29
+	Dm
		669713 PSMD3_DROME (1-494): 0: 600: 100.00		Q9V405_DROME (1-425): 2.69e-118: 352: 35.29
+	Dm
		669685 PSMD3_DROME (1-494): 0: 600: 100.00		PRS4_DROME (1-430): 3.95e-117: 351: 38.89
+	Dm
		669746 PSMD3_DROME (1-494): 0: 600: 100.00		Q9W414_DROME (33-429): 1.46e-116: 347: 42.75
+	Hs
		210912 PSMD3_HUMAN (4-494): 0: 578: 57.81		PRS4_HUMAN (1-430): 1.02e-120: 360: 40.28
+	Hs
		210913 PSMD3_HUMAN (4-494): 0: 578: 57.81		PRS8_HUMAN (25-430): 3.46e-120: 357: 45.57
+	Hs
		210916 PSMD3_HUMAN (4-494): 0: 578: 57.81		PRS10_HUMAN (34-429): 9.58e-118: 350: 41.60
+	Hs
		210883 PSMD3_HUMAN (4-494): 0: 578: 57.81		PRS6B_HUMAN (17-425): 4.21e-116: 347: 36.84
+	Sc
		750950 RPN3_YEAST (7-492): 9.6e-164: 475: 31.99		PRS7_YEAST (1-433): 5.55e-128: 379: 67.24
+	Sc
		817082 RPN3_YEAST (7-492): 9.6e-164: 475: 31.99		PRS8_YEAST (41-430): 1.24e-115: 346: 45.13