Protein: RPN3
26S proteasome regulatory subunit RPN3

Gene: RPN3
Organism: Saccharomyces cerevisiae S288C
Interactions: 157
UniProt ID: P40016

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008541 - proteasome regulatory particle, lid subcomplex
GO:0030234 - enzyme regulator activity
GO:0042176 - regulation of protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

817092

RPN7
26S proteasome regulatory subunit RPN7

11

16

Small-scale

0.979

High

817102

RPN5
26S proteasome regulatory subunit RPN5

10

12

Small-scale

0.974

High

817103

RPN6
26S proteasome regulatory subunit RPN6

10

16

Small-scale

0.970

High

738310

RPN12
26S proteasome regulatory subunit RPN12

8

3

Small-scale

0.969

High

817099

RPN8
26S proteasome regulatory subunit RPN8

6

12

Small-scale

0.938

High

314875

SEM1
26S proteasome complex subunit SEM1

8

0

Small-scale

0.912

High

740168

RPN2
26S proteasome regulatory subunit RPN2

5

8

Small-scale

0.912

High

817088

RPN9
26S proteasome regulatory subunit RPN9

4

10

High-throughput

0.892

High

817067

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

28

12

Small-scale

0.767

High

803555

RPN1
26S proteasome regulatory subunit RPN1

8

8

Small-scale

0.749

High

806721

RPN10
26S proteasome regulatory subunit RPN10

6

1

Small-scale

0.735

High

750950

PRS7
26S proteasome regulatory subunit 7 homolog

5

14

Small-scale

0.712

High

645173

PSB4
Proteasome subunit beta type-4

5

9

Small-scale

0.706

High

750844

PRS6B
26S proteasome regulatory subunit 6B homolog

5

12

Small-scale

0.706

High

817068

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

4

3

High-throughput

0.694

High

803126

ECM29
Proteasome component ECM29

4

1

High-throughput

0.691

High

743988

RAD23
UV excision repair protein RAD23

4

10

Small-scale

0.683

High

817075

RPN14
26S proteasome regulatory subunit RPN14

3

2

High-throughput

0.667

High

817073

PSD10
Probable 26S proteasome regulatory subunit p28

5

1

Small-scale

0.654

High

817082

PRS8
26S proteasome regulatory subunit 8 homolog

3

14

High-throughput

0.650

High

750673

PRS6A
26S proteasome regulatory subunit 6A

3

14

High-throughput

0.640

High

817058

RPN3
26S proteasome regulatory subunit RPN3

1

3

High-throughput

0.618

High

636585

PSA7
Probable proteasome subunit alpha type-7

2

8

High-throughput

0.611

High

800844

PSB1
Proteasome subunit beta type-1

2

11

High-throughput

0.611

High

817061

PSA4
Proteasome subunit alpha type-4

2

8

High-throughput

0.611

High

817062

PRS4
26S proteasome regulatory subunit 4 homolog

2

13

High-throughput

0.601

High

817076

PRS10
26S proteasome subunit RPT4

2

17

High-throughput

0.601

High

670755

SIS1
Protein SIS1

3

2

High-throughput

0.587

High

150286

RPN13
26S proteasome regulatory subunit RPN13

2

0

High-throughput

0.585

High

661521

PSA2
Proteasome subunit alpha type-2

2

7

High-throughput

0.584

High

817078

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

2

2

Small-scale

0.584

High

509569

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

8

Small-scale

0.543

High

741653

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.536

High

392788

HSP82
ATP-dependent molecular chaperone HSP82

2

2

High-throughput

0.521

High

817059

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.504

High

554699

YPK1
Serine/threonine-protein kinase YPK1

1

2

High-throughput

0.494

High

811263

RGA1
Rho-type GTPase-activating protein 1

1

1

High-throughput

0.494

High

364557

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.489

High

636666

PSA1
Proteasome subunit alpha type-1

1

7

High-throughput

0.479

High

661410

PSA3
Proteasome subunit alpha type-3

1

8

High-throughput

0.479

High

662041

PSB6
Proteasome subunit beta type-6

1

11

High-throughput

0.479

High

668392

PSB2
Proteasome subunit beta type-2

1

8

High-throughput

0.479

High

675247

PSB3
Proteasome subunit beta type-3

1

9

High-throughput

0.479

High

679723

CDC48
Cell division control protein 48

1

4

High-throughput

0.479

High

721260

PSB5
Proteasome subunit beta type-5

1

11

High-throughput

0.479

High

721311

PSB7
Proteasome subunit beta type-7

1

10

High-throughput

0.479

High

735933

PSA5
Proteasome subunit alpha type-5

1

7

High-throughput

0.479

High

817060

PSA6
Proteasome subunit alpha type-6

1

7

High-throughput

0.479

High

760535

FAB1
1-phosphatidylinositol 3-phosphate 5-kinase FAB1

1

3

High-throughput

0.470

High

807667

HRB1
Serine/arginine

1

1

High-throughput

0.470

High

807868

VPS45
Vacuolar protein sorting-associated protein 45

1

1

High-throughput

0.470

High

808404

HAL5
Serine/threonine-protein kinase HAL5

1

1

High-throughput

0.470

High

817069

ALY2
Arrestin-related trafficking adapter 3

1

2

High-throughput

0.470

High

817096

RGA2
Rho-type GTPase-activating protein 2

1

2

High-throughput

0.470

High

776583

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

524064

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

526789

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

676029

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

742859

HSP79
Heat shock protein homolog SSE2

1

4

High-throughput

0.445

High

504236

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

579460

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.437

High

616425

SEC18
Vesicular-fusion protein SEC18

1

5

High-throughput

0.437

High

689482

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.437

High

707197

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

727056

HS104
Heat shock protein 104

1

1

High-throughput

0.437

High

779240

CENPA
Histone H3-like centromeric protein CSE4

1

1

High-throughput

0.437

High

802200

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

817063

MLP2
Protein MLP2

1

1

High-throughput

0.437

High

817064

PSMD9
Probable 26S proteasome regulatory subunit p27

1

1

Small-scale

0.437

High

817079

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.437

High

817086

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.437

High

817100

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

817104

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

817106

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.437

High

545004

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.407

High

617398

GBB
Guanine nucleotide-binding protein subunit beta

1

2

High-throughput

0.407

High

752303

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

810691

TCPB
T-complex protein 1 subunit beta

1

1

High-throughput

0.407

High

811319

CAJ1
Protein CAJ1

1

2

High-throughput

0.407

High

817070

HLJ1
Protein HLJ1

1

1

High-throughput

0.407

High

817077

JJJ1
J protein JJJ1

1

1

High-throughput

0.407

High

798555

HSM3
DNA mismatch repair protein HSM3

5

0

Small-scale

0.369

High

797841

FTH1
Iron transporter FTH1

2

0

High-throughput

0.307

High

817084

ESC1
Silent chromatin protein ESC1

2

0

High-throughput

0.305

High

567684

ACOX
Acyl-coenzyme A oxidase

1

0

High-throughput

0.282

High

809459

MPT5
Suppressor protein MPT5

1

0

High-throughput

0.282

High

817065

MND2
Anaphase-promoting complex subunit MND2

1

0

High-throughput

0.282

High

817083

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.282

High

459098

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.279

Low

797956

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.279

Low

817080

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

0

High-throughput

0.279

Low

359014

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

0

High-throughput

0.269

Low

564661

STE12
Protein STE12

1

0

High-throughput

0.269

Low

585285

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.269

Low

604433

KHSE
Homoserine kinase

1

0

High-throughput

0.269

Low

636804

PUR6
Phosphoribosylaminoimidazole carboxylase

1

0

High-throughput

0.269

Low

638010

PRP5
Pre-mRNA-processing ATP-dependent RNA helicase PRP5

1

0

High-throughput

0.269

Low

639864

SIR1
Regulatory protein SIR1

1

0

High-throughput

0.269

Low

677682

MRC1
Mediator of replication checkpoint protein 1

1

0

High-throughput

0.269

Low

734262

DBF4
DDK kinase regulatory subunit DBF4

1

0

High-throughput

0.269

Low

757860

PTH2
Peptidyl-tRNA hydrolase 2

1

0

High-throughput

0.269

Low

758450

YKK0
Probable intramembrane protease YKL100C

1

0

High-throughput

0.269

Low

778876

FOLC
Probable folylpolyglutamate synthase

1

0

High-throughput

0.269

Low

797520

PEX32
Peroxisomal membrane protein PEX32

1

0

High-throughput

0.269

Low

812330

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.269

Low

816135

SDD1
Uncharacterized protein YEL057C

1

0

High-throughput

0.269

Low

817074

CWH41
Mannosyl-oligosaccharide glucosidase

1

0

High-throughput

0.269

Low

817091

BSC2
Bypass of stop codon protein 2

1

0

High-throughput

0.269

Low

817094

VTA1
Vacuolar protein sorting-associated protein VTA1

1

0

High-throughput

0.269

Low

817097

TLG2
t-SNARE affecting a late Golgi compartment protein 2

1

0

High-throughput

0.269

Low

817105

YD199
Putative metabolite transport protein YDL199C

1

0

High-throughput

0.269

Low

817107

SNF8
Vacuolar-sorting protein SNF8

1

0

High-throughput

0.269

Low

795701

FUI1
Uridine permease

1

0

High-throughput

0.265

Low

633256

CKS1
Cyclin-dependent kinases regulatory subunit

1

0

Small-scale

0.261

Low

150051

YP035
Putative uncharacterized protein YPL035C

1

0

High-throughput

0.249

Low

313521

OPI9
Putative uncharacterized protein OPI9

1

0

High-throughput

0.249

Low

410159

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433666

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

435122

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

441932

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

455087

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

503067

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

513030

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

557598

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

0

Small-scale

0.249

Low

558739

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

603056

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.249

Low

647121

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

667090

CG22
G2/mitotic-specific cyclin-2

1

0

Small-scale

0.249

Low

674650

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

677413

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

679047

FUB1
Silencing boundary-establishment protein FUB1

1

0

High-throughput

0.249

Low

734998

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

747391

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

747878

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

753394

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

764084

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

778353

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

795003

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

811674

DSS1
Exoribonuclease II, mitochondrial

1

0

Small-scale

0.249

Low

815127

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.249

Low

817066

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

817071

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

817072

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

817081

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

817085

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

817087

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

817089

SIZ1
E3 SUMO-protein ligase SIZ1

1

0

High-throughput

0.249

Low

817090

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

817093

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

817095

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

817098

ESA1
Histone acetyltransferase ESA1

1

0

Small-scale

0.249

Low

817101

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.249

Low

577140

SEC63
Protein translocation protein SEC63

1

0

High-throughput

0.232

Low

590635

HSP26
Heat shock protein 26

1

0

High-throughput

0.232

Low

597736

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.232

Low

812188

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025