HitPredict

Interactor 1: V2R (P30518)
Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor)
Gene: AVPR2

Interactor 2: GNAS2 (P63092)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
Gene: GNAS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	15782186
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	7tm_1~G-alpha
Common GO terms	GO:0005886 - plasma membrane GO:0007190 - activation of adenylate cyclase activity GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 371 Hs			1 394
+	Hs
		429010 ADRB2_HUMAN (1-364): 8.97e-80: 252: 18.82		GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00
+	Hs
		602211 DRD5_HUMAN (1-350): 2.34e-68: 224: 20.73		GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00
+	Hs
		391305 ADRB2_HUMAN (1-364): 8.97e-80: 252: 18.82		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		429011 ADRB2_HUMAN (1-364): 8.97e-80: 252: 18.82		GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09
+	Hs
		428884 ADRB2_HUMAN (1-364): 8.97e-80: 252: 18.82		GNAI3_HUMAN (1-394): 1.06e-155: 444: 38.58
+	Hs
		428911 ADRB2_HUMAN (1-364): 8.97e-80: 252: 18.82		GNAT2_HUMAN (9-394): 4.93e-149: 427: 39.38
+	Hs
		391347 OPRD_HUMAN (2-363): 3.48e-64: 210: 23.22		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		450979 OPRM_HUMAN (1-371): 2.05e-66: 217: 19.57		GNAO_HUMAN (1-394): 2.43e-153: 438: 40.66
+	Hs
		450984 OPRD_HUMAN (2-363): 3.48e-64: 210: 23.22		GNAO_HUMAN (1-394): 2.43e-153: 438: 40.66
+	Hs
		837638 KISSR_HUMAN (4-342): 1.06e-63: 210: 18.26		GNAQ_HUMAN (11-394): 9.45e-151: 432: 38.02
+	Hs
		580402 DRD5_HUMAN (1-350): 2.34e-68: 224: 20.73		GNAZ_HUMAN (1-393): 2.98e-142: 410: 37.15
+	Hs
		825680 MTR1B_HUMAN (21-340): 1.8e-11: 66.6: 22.46		GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00
+	Hs
		391355 MTR1B_HUMAN (21-340): 1.8e-11: 66.6: 22.46		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		825681 MTR1B_HUMAN (21-340): 1.8e-11: 66.6: 22.46		GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09
+	Hs
		444688 MTR1B_HUMAN (21-340): 1.8e-11: 66.6: 22.46		GNAI3_HUMAN (1-394): 1.06e-155: 444: 38.58
+	Hs
		675592 KISSR_HUMAN (4-342): 1.06e-63: 210: 18.26		GNA15_HUMAN (9-394): 1.58e-77: 245: 36.71