HitPredict

Interactor 1: PSA3 (P25788)
Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7)
Gene: PSMA3

Interactor 2: AMRA1 (Q9C0C7)
Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3)
Gene: AMBRA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25499913
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 1298
+	Hs
		700726 PSA5_HUMAN (1-239): 1.18e-96: 284: 31.97		AMRA1_HUMAN (1-1298): 0: 1596: 100.00
+	Hs
		954900 PSA6_HUMAN (4-242): 5.9e-96: 283: 29.34		AMRA1_HUMAN (1-1298): 0: 1596: 100.00
+	Hs
		681712 PSA4_HUMAN (4-236): 1.73e-94: 279: 27.43		AMRA1_HUMAN (1-1298): 0: 1596: 100.00
+	Hs
		165408 PSA7_HUMAN (7-237): 1.54e-93: 277: 31.76		AMRA1_HUMAN (1-1298): 0: 1596: 100.00
+	Hs
		681319 PSA3_HUMAN (1-255): 1.86e-97: 287: 100.00		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Hs
		681473 PSA3_HUMAN (1-255): 1.86e-97: 287: 100.00		FBXW7_HUMAN (164-314): 4.21e-18: 92.2: 10.53
+	Hs
		700703 PSA5_HUMAN (1-239): 1.18e-96: 284: 31.97		FBXW7_HUMAN (164-314): 4.21e-18: 92.2: 10.53
+	Hs
		954874 PSA6_HUMAN (4-242): 5.9e-96: 283: 29.34		FBXW7_HUMAN (164-314): 4.21e-18: 92.2: 10.53
+	Hs
		681694 PSA4_HUMAN (4-236): 1.73e-94: 279: 27.43		FBXW7_HUMAN (164-314): 4.21e-18: 92.2: 10.53
+	Hs
		681505 PSA3_HUMAN (1-255): 1.86e-97: 287: 100.00		TBL1R_HUMAN (28-201): 1.6e-14: 80.1: 17.98