HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: FOXO4 (P98177)
Forkhead box protein O4 (Fork head domain transcription factor AFX1)
Gene: FOXO4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 0.60 0.670

The method score is based on:

Property Details
Experiments 15688030, 16272144, 14690436
Identification Methods affinity chromatography technology, pull down, enzymatic study, protein kinase assay
Interaction Type physical association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006979 - response to oxidative stress
and 3 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 480
Hs

1 505
+ Rn
+ Hs
+ Mm
+ Hs
+ Dm
+ Ce
+ Ce
+ Hs
+ Sp
+ Ce
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024